简介：AIM:Toevaluatetheefficacyofthe14-dmoxifloxacinbasedtripletherapyforthesecond-lineeradicationofHelicobacterpylori(H.pylori)infection.METHODS:Between2011and2013,weconductedaretrospectivereviewofthemedicalrecordsof160patientswhohadexperiencedfailureoftheirfirst-lineprotonpumpinhibitor-basederadicationtherapyandsubsequentlyreceivedthemoxifloxacin-basedtripletherapyasasecond-lineeradicationtreatmentregimen.Thepatientswhoweretreatedwiththemoxifloxacinbasedtripletherapy(oral20mgrabeprazoleb.i.d.,1000mgamoxicillinb.i.d.,and400mgmoxifloxacinq.d.)for7dwereassignedtotheRAM-7group(n=79)whilethosewhotookthemfor14dayswereassignedtoRAM-14group(n=81).Theeradicationratesforbothgroupsweredeterminedbyintentionto-treat(ITT)andper-protocol(PP)analyses.ITTanalysiscomparedthetreatmentgroupsasoriginallyallocatedwhilethePPanalysisincludingonlythosepatientswhohadcompletedthetreatmentasoriginallyallocated.SuccessfuleradicationtherapyforH.pyloriinfectionwasdefinedasthedocumentationofanegative13C-ureabreathtest4wkaftertheendoftheeradicationtreatment.RESULTS:TheoverallITTeradicationratewas76.2%(122/160).ThefinalITTeradicationrateswere70.8%(56/79;95%CI:63.3%-77.1%)intheRAM-7groupand81.4%(66/81;95%CI:74.6%-88.3%)intheRAM-14group(P=0.034).TheoverallPPeradicationratewas84.1%(122/145),andthefinalPPeradicationrateswere77.7%(56/72;95%CI:70.2%-85.3%)intheRAM-7groupand90.4%(66/73;95%CI:82.8%-98.1%)intheRAM-14group(P=0.017).TheH.pylori-eradicationratesintheRAM-14groupweresignificantlyhighercomparedwiththatoftheRAM-7groupaccordingtoboththeITT(P=0.034)andthePPanalyses(P=0.017).Bothgroupsexhibitedgoodtreatmentcompliance(RAM-7/RAM-14group:100%/100%).Theadverseeventrateswere19.4%(14/72)and20.5%(15/73)intheRAM-7andRAM-14groups,respectively(P=0.441).Adverseeventsoccurredin14

简介：Objective:Panitumumabadministeredasmonotherapyincolorectalcancer(CRC)hasshownresponseanddiseasestabilizationratesofapproximately30%.Thecurrentstudyaimedtoevaluatetheprogression-freesurvival(PFS)andoverallsurvival(OS)ofpatientswithmetastaticcolorectalcancer(mCRC)treatedwithpanitumumabevery3weeksasasecondlinetreatment.Methods:Thisstudyisaretrospectiveanalysisof18patients,agedmorethan18years,withwild-typeKRASexon2mCRCtreatedwithpanitumumabasasecond-linesingleagentafterprogressiononfirst-linechemotherapy.Results:Themediannumberofcoursesreceivedwas10(range,4-29),andthemediandurationoftreatmentwas30weeks(range,12-96weeks).Afteramedianfollow-upperiodof13months,themedianPFSwas6months(range,4.3-7.7months)andthemedianOSwas11months(range,7.4-14.5months).ThemedianPFSwas4monthsforpatientswith

简介：现在的文章与寓言的退化为一些非线性的混合方程处理倾斜的衍生物问题，它作为一种特殊情况包括Tricomi问题。首先，为方程的问题的明确的表达被给；下次，上述问题的解决方案的表示和估计被获得；最后，这些问题的解决方案的存在被连续重复和这些问题的答案的紧密原则证明。在这篇文章，也就是，作者使用复杂方法在椭圆形的域的复杂函数和在夸张领域的夸张复杂函数被使用。

简介：Lungcanceristhemostfrequentlydiagnosedcancerandaleadingcauseofcancermortalityworldwide,withadenocarcinomabeingthemostcommonhistologicalsubtype.Deeperunderstandingofthepathobiologyofnon-smallcelllungcancer(NSCLC)hasledtothedevelopmentofsmallmoleculesthattargetgeneticmutationsknowntoplaycriticalrolesinprogressiontometastaticdiseaseandtoinfluenceresponsetotargetedtherapies.Theprinciplegoalofprecisionmedicineistodefinethosepatientpopulationsmostlikelytorespondtotargetedtherapies.However,thecancergenomelandscapeiscomposedofrelativelyfew"mountains"[representingthemostcommonlymutatedgeneslikeKRAS,epidermalgrowthfactor(EGFR),andanaplasticlymphomakinase(ALK)]andavastnumberof"hills"(representinglowfrequencybutpotentiallyactionablemutations).Low-frequencylesionsthataffectadruggablegeneproductallowarelativelysmallpopulationofcancerpatientsfortargetedtherapytobeselected.

简介：

简介：乡村歌手贝茨以编词谱曲自弹自唱而出名，然而他却染上了吸毒的恶习，并偷盗他人财物。养母和同事不计前嫌，以宽大的胸怀鼓励他重新做人。今年，他的唱片集终于问世，再度受到了歌迷的热烈欢迎。

简介：Alookattheongoing'5pointsin1line'coastlinedevelopmentprojectinLiaoning,NortheastChinaLIAONINGProvinceinNortheastChinawasoncethecountry'sindustrialengine.WithinadecadeofNewChina'sfounding,itwaschurningouteverythingfromcoalandsteeltofighterjets.Buttheenginesplutteredoutinthemid-1990s,whenmanyofLiaoning'sstate-owned

简介：

简介：Reformandopeningis,inessence,asecondrevolution.---DengXiaopingAhistoricreorientationtookplacein1978,whenDengXiaopingstoodoutasthechiefarchitectofreformandopening.Hestartedthecountryonitsownindus-trialrestructuring.Chinahashaddazzlingannualgrowthof9.7percent(1978-

简介：Oneday,acatandherfourkittensranintoadog.Whenthekittenscowered,thecatletoutaseriesofloudbarks,scaringthedogaway.Turningtoherkittens,thecatsaid,"Youseehowimportantitistoknowasecondlanguage."

简介：从本期起,本刊为大家设了一个新天地——边读边练。在这里,大家一起读有趣的短文、记短语、做练习,justenjoyyourself!

简介：

简介：

简介：

简介：Dropmealine是一个非常地道的口语。在没有电话，没有email的时代，它最初表示“有什么消息简单写几个字寄过来吧”。如今，通讯发达。大家都用手机sendmessage，email，fax等等，很少用写信这种“古老方式”，但这个说法却一直沿用至今。衍生义为“记得要和我联系啊”!

简介：对线线的描述拓扑的关系尽管许多努力被做了，仍然是一个未解决的问题。这个问题涉及象空间质问，空间分析和制图综合那样的许多实际应用。开发一条健全、有效的途径描述线线关系，它是第一必要排队定义一个个人的拓扑学，即，本地拓扑学。连接的度的概念在一根线的几何结构被用于拓扑的差别的鉴定。一根线的一般拓扑的定义被给，即，端点集合和内部点设定。这个定义能被用于不同尺寸的嵌入的空格，合作尺寸是否等于或比零大。在这个基础上，打电话给4intersection-and-difference的一个通用模型为对基本线线的描述被建立拓扑的关系，一张概念的邻居图与拓扑的距离的考虑在之上被造。建议模型能在/R~1和/R~2代表在线片断之间的拓扑的变化，和基本关系的性质，这被结束。

简介：ItisacommonpracticeinChinatouseaninsulatedsilkjacklad-derinthelive-lineworktoenterthe500kVEHVelectricfield.WuhanHighVoltageResearchInstitutehassuccessfullycarriedoutsuchoperatingperformanceatthemeetingofESMO-90inCanada.(Fig.1)Theoperatingprocedureisnowrecommendedasfollows.

简介：Iamverysatisfiedwithmylife,whichisvariedandcolourful,distinctive,andhappyexceptforsomefrustrations.Inthepast,IwishedIwouldhaveasecondlifelikethisone.NowIgiveuptheideabecauseIamconfidentthatthe

简介：话题呈现某英文杂志中学生专栏正在征集“二孩政策”放开后孩子们的意见。你们班就“Doyouagreethatyourparentshaveasecondchild?”这一话题展开了讨论。

简介：