简介:Inthispaper,thesupercouvergenceofaclassofWilson-likeelementsisconsidered,andasuperconvergentestimateofWilson-likeelementsisobtainedforstrongregularmeshes.
简介:AbstractAntiphospholipid syndrome (APS) is a systemic autoimmune disease defined by thrombotic or obstetrical events and persistent antiphospholipid antibodies (aPLs). Chemokine-like factor-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system and may closely related to APS. This review aimed to systematically summarize the possible effects of CMTM on APS. Publications were collected from PubMed and Web of Science databases up to August 2020. CKLF, CKLFSF, CMTM, antiphospholipid syndrome, immune cells, and immune molecules were used as search criteria. Immune cells, including neutrophil, dendritic cells (DCs), T-cells, B-cells, and inflammatory cytokines, play an important role in the development of APS. Chemokine-like factor 1 (CKLF1) has a chemotactic effect on many cells and can affect the expression of inflammatory cytokines and adhesion molecules through the nuclear factor-kB (NF-kB) pathway or mitogen-activated protein kinase (MARK) pathway. CKLF1 can participate in the maturation of DCs, T lymphocyte activation, and the activation of neutrophils through the MAPK pathway. CMTM1 may act on Annexin A2 by regulating Ca2+ signaling. CMTM2 and CMTM6 are up-regulated in neutrophils of APS patients. Some CMTM family members influence the activation and accumulation of platelets. CMTM3 and CMTM7 are binding partners of B-cell linker protein (BLNK), thereby linking B cell receptor (BCR) and activating BLNK-mediated signal transduction in B cells. Moreover, CMTM3 and CMTM7 can act on DCs and B-1a cell development, respectively. CMTM may have potential effects on the development of APS by acting on immune cells and immune molecules. Thus, CMTM may act as a novel prognostic factor or immunomodulatory treatment option of APS.
简介:Inthispaperweimprovethetwoversionsofthetwo-sidedprojectedquasi-Newtonmethod-onewasproposedbyNocedal&Overtonin[1]andtheotherwasdiscussedinourpreviouspaper,byintroducingthreedifferentmeritfunctionstomakeinexactone-dimensionalsearches.Itisshownthattheseimprovedquasi-Newtonalgorithmshavegainedglobalconvergencepropertywhichisnotpossessedbytheoriginaltwoalgorithms.
简介:Inthepresentstudywehavefoundthatproto-oncogenec-fosproteincanexpressinthenoradrenergicneuronsofrathindbrainfollowingperipheralelectricalstimulation.Ratsweregivenperipheralelectricalstimulationviathinstainlesssteelpinsinsertedintothepointsnearkneejoint(S36)andanklejoint(Sp6)whichmimicthemanipulationofelectroacupuncture(EA)performedinhumans.Animalswereperfusedfordoublestainingimmunohistochemistry2haftertheterminationofEA.InratssubjectedtoEAstimulationFos-likeproteinwasfoundinthetyrosinehydroxylase(TH)-likeimmunoreactiveneuronsinrathindbrain.TheFosandTHcoex-istingneuronsweredistributedinthelocuscoeruleus,solitarytractnucleus,ventrolateralmedul-la,periaqeductalgray,aswellassuperiorcolliculus.ThepercentageofthecoexistingneuronscomparedwiththetotalnumberofneuronscontainingFos-likeproteininthesenucleirangedfrom6%to32%.Theresultssuggestthatthenoradrenergicneuronsintheseregionsmaybeac-tivtedbyacupuncturestimulation.
简介:同步讲解SectionA1.Let’sseethepandasfirst.让我们先看熊猫吧.(1)此句是祈使句,let’s用来表示征求对方意见或向对方提出建议。Let’s后的动词要用动词原形,句式结构为letsb(not)dosth,意为'让某人(不)做某事',sb为人称代词时则用宾格。其肯定回答:OK/Allright/Thatsoundsgood.否定回答:Sorry,but.../I’dloveto,but...比较:let’s与letusLet’s是letus的缩写形式,但let’s指向对方提出建议,
简介:本单元知识网络同步讲解SectionA1.Let’sseethepandasfirst.让我们先看熊猫吧.(1)此句是祈使句,let’s用来表示征求对方意见或向对方提出建议。Let’s后的动词要用动词原形,句式结构为letsb(not)dosth,意为'让某人(不)做某事',sb为人称代词时则用宾格。其肯定回答:OK/Allright/Thatsoundsgood.否定回答:Sorry,but.../I’dloveto,but...