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  • 简介:每期一张单词卡,你可以剪下.随身带。认识了单词.翻译小诗,寄给《芝麻开门》.争当“小翻译家”。最好附上你的大头贴.让你可爱的笑脸有机会在杂志里亮相!

  • 标签: 小学生 英语学习 学习方法 阅读 英语单词
  • 简介:同学们,你知道如何描述一个人过去的样子吗?都有哪些常用表达呢?请看Talkingaboutwhatyouusedtobelike。

  • 标签: 中等教育 英语 阅读 理解
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  • 简介:同学们,你们知道如何描述一个人过去的样子吗?英语中都有哪些常用表达呢?请看Talkingaboutwhatyouusedtobelikeo

  • 标签: 中学 英语 课外阅读 阅读材料
  • 简介:“What/Howabout…?”与“Wouldyoulike/love…?”都常用来表示婉转地请求或建议。这两种句式有不同之处。

  • 标签: “What “Would 句式 请求 表示
  • 简介:AbstractAntiphospholipid syndrome (APS) is a systemic autoimmune disease defined by thrombotic or obstetrical events and persistent antiphospholipid antibodies (aPLs). Chemokine-like factor-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system and may closely related to APS. This review aimed to systematically summarize the possible effects of CMTM on APS. Publications were collected from PubMed and Web of Science databases up to August 2020. CKLF, CKLFSF, CMTM, antiphospholipid syndrome, immune cells, and immune molecules were used as search criteria. Immune cells, including neutrophil, dendritic cells (DCs), T-cells, B-cells, and inflammatory cytokines, play an important role in the development of APS. Chemokine-like factor 1 (CKLF1) has a chemotactic effect on many cells and can affect the expression of inflammatory cytokines and adhesion molecules through the nuclear factor-kB (NF-kB) pathway or mitogen-activated protein kinase (MARK) pathway. CKLF1 can participate in the maturation of DCs, T lymphocyte activation, and the activation of neutrophils through the MAPK pathway. CMTM1 may act on Annexin A2 by regulating Ca2+ signaling. CMTM2 and CMTM6 are up-regulated in neutrophils of APS patients. Some CMTM family members influence the activation and accumulation of platelets. CMTM3 and CMTM7 are binding partners of B-cell linker protein (BLNK), thereby linking B cell receptor (BCR) and activating BLNK-mediated signal transduction in B cells. Moreover, CMTM3 and CMTM7 can act on DCs and B-1a cell development, respectively. CMTM may have potential effects on the development of APS by acting on immune cells and immune molecules. Thus, CMTM may act as a novel prognostic factor or immunomodulatory treatment option of APS.

  • 标签: Antiphospholipid syndrome CMTM Pathogenesis
  • 简介:基于Thiele连分式,重新建立了求解非线性方程的经典的Newton迭代公式.为了避免求导数运算,采用差商可以近似代替导数的办法,得到Newton迭代方法的几个变体并给出了其收敛的阶数.最后,数值实例证实了这些迭代格式是有效的.

  • 标签: 连分式 NEWTON迭代 差商 收敛阶数
  • 简介:首先将定义在闭凸多面锥上的广义互补问题转化为一个等价的非线性方程组.然后利用一种修正的光滑Newton法求解该非线性方程组,并在一定的条件下,证明了算法具有全局收敛性.

  • 标签: 互补问题 算法 收敛性
  • 简介:Inthispaperweimprovethetwoversionsofthetwo-sidedprojectedquasi-Newtonmethod-onewasproposedbyNocedal&Overtonin[1]andtheotherwasdiscussedinourpreviouspaper,byintroducingthreedifferentmeritfunctionstomakeinexactone-dimensionalsearches.Itisshownthattheseimprovedquasi-Newtonalgorithmshavegainedglobalconvergencepropertywhichisnotpossessedbytheoriginaltwoalgorithms.

  • 标签: projected sided MERIT gained QUASI possessed
  • 简介:Inthepresentstudywehavefoundthatproto-oncogenec-fosproteincanexpressinthenoradrenergicneuronsofrathindbrainfollowingperipheralelectricalstimulation.Ratsweregivenperipheralelectricalstimulationviathinstainlesssteelpinsinsertedintothepointsnearkneejoint(S36)andanklejoint(Sp6)whichmimicthemanipulationofelectroacupuncture(EA)performedinhumans.Animalswereperfusedfordoublestainingimmunohistochemistry2haftertheterminationofEA.InratssubjectedtoEAstimulationFos-likeproteinwasfoundinthetyrosinehydroxylase(TH)-likeimmunoreactiveneuronsinrathindbrain.TheFosandTHcoex-istingneuronsweredistributedinthelocuscoeruleus,solitarytractnucleus,ventrolateralmedul-la,periaqeductalgray,aswellassuperiorcolliculus.ThepercentageofthecoexistingneuronscomparedwiththetotalnumberofneuronscontainingFos-likeproteininthesenucleirangedfrom6%to32%.Theresultssuggestthatthenoradrenergicneuronsintheseregionsmaybeac-tivtedbyacupuncturestimulation.

  • 标签: COEXISTENCE Fos-like protein TYROSINE HYDROXYLASE PERIPHERAL
  • 简介:同步讲解SectionA1.Let’sseethepandasfirst.让我们先看熊猫吧.(1)此句是祈使句,let’s用来表示征求对方意见或向对方提出建议。Let’s后的动词要用动词原形,句式结构为letsb(not)dosth,意为'让某人(不)做某事',sb为人称代词时则用宾格。其肯定回答:OK/Allright/Thatsoundsgood.否定回答:Sorry,but.../I’dloveto,but...比较:let’s与letusLet’s是letus的缩写形式,但let’s指向对方提出建议,

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  • 简介:本单元知识网络同步讲解SectionA1.Let’sseethepandasfirst.让我们先看熊猫吧.(1)此句是祈使句,let’s用来表示征求对方意见或向对方提出建议。Let’s后的动词要用动词原形,句式结构为letsb(not)dosth,意为'让某人(不)做某事',sb为人称代词时则用宾格。其肯定回答:OK/Allright/Thatsoundsgood.否定回答:Sorry,but.../I’dloveto,but...

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