简介:Everyearlymorning,birds'happysingingwakesmeup.Igetdressedquicklyandhaveawashandbrushup,thenwatchbirdsandlistentothemsinginghappilyinthetrees.Thesingingofdifferentkindsofbirdssoundslikeapieceofbeautifulsymphonicmusic.Birds’singingmakesmerelaxedandhappyanditalsorecallsmesomethingofthePast.
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简介:AbstractThe chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system. Abnormal expression of CMTM is associated with the development of various diseases. This article summarizes the relevant research on the role of the CMTM family in immune disorders. This information will increase our understanding of pathogenesis and identify promising targets for the diagnosis and treatment of autoimmune diseases. The CMTM family is highly expressed in peripheral blood mononuclear cells. CKLF1 may be involved in the development of arthritis through its interaction with C-C chemokine receptor 4. CKLF1 is associated with the pathogenesis of lupus nephritis and psoriasis. Both CMTM4 and CMTM5 are associated with the pathogenesis of systemic lupus erythematosus. CMTM1, CMTM2, CMTM3, and CMTM6 play a role in rheumatoid arthritis, systemic sclerosis, Sjögren syndrome, and anti-phospholipid syndrome, respectively. The CMTM family has been implicated in various autoimmune diseases. Further research on the mechanism of the action of CMTM family members may lead to the development of new treatment strategies for autoimmune diseases.
简介:牛顿的重复为单个Toeplitz矩阵的组逆的计算被修改。在每次重复,重复矩阵被一个矩阵与一个低排水量等级接近。因为重复矩阵的排水量结构,涉及牛顿的重复的thematrix向量增加能高效地被做。我们证明修改牛顿重复的集中仍然是很快的。数字结果被介绍表明建议方法的快集中。
简介:首先用微分中值定理推出了Newton-Leibniz公式,同时也用Newton-Leibniz公式推出了三个微分中值定理,从而证明了微分中值定理与Newton-Leibniz公式可互相证明.
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简介:Inthisstudy,weuseinexactnewtonmethodstofindsolutionsofnonlinear,nondifferenti-ableoperatorequationsonBanachspaceswithaconvergencestructure.ThistechniqueinvolvestheintroductionofageneralizednormasanoperatorfromalinearspaceintoapartiallyorderedBanachspace.Inthiswaythemetricpropertiesoftheexaminedproblemcanbeanalyzedmoreprecisely.Moreover,thisapproachallmvsustoderivefromthesametheorem,ontheonehand,semi-localresultsofKantorovich-type,andontheotherhand,globalresultsbasedonmono-tonicityconsiderations.Furthermore,iveshowthatspecialcasesofourresultsreducetothecorrespondingonesalreadyintheliterature.Finally>ourresultsareusedtosolveintegralequationsthatcannotbesolvedwithexistingmethods.
简介:摘要:本文改进了一种基于Newton-Raphson的数字图像相关算法。首先,介绍了应用广泛的相关函数及采用了标准化协方差相关函数来分析整数像素的位移,并以此作为初值;其次,介绍了Newton—Raphson方法在亚像素分析中的应用,对优化函数的一阶偏导和二阶偏导(Hessian矩阵)进行了优化,建立了亚像素分析的迭代公式;最后,为了提高分析效率,对数字图像的离散灰度值进行了全场插值。仿真测试表明本文提出算法的合理性和正确性,该算法能够有效用于位移和应变的分析,对算法的优化处理能够显著提高计算速度。
简介:AbstractSchnitzler syndrome is a rare disease of adult-onset with main features including chronic urticarial rash, recurrent fever, arthralgia or arthritis, monoclonal gammopathy of undetermined significance (MGUS), and marked systemic inflammation. Schnitzler syndrome is often underdiagnosed. Patients with Schnitzler syndrome may present to dermatologists and allergists for urticaria, hematologists for MGUS, or rheumatologists for arthritis. It is important to recognize Schnitzler syndrome for its remarkable response to interleukin (IL)-1 blockade. Besides, many cases of Schnitzler-like syndromes do not meet the diagnostic criteria of classical Schnitzler syndrome but display excellent response to IL-1 inhibitors. The overly produced IL-1 is the result of a somatic mosaic gain of function mutation of NLRP3 (nucleotide-binding oligomerization domain [NOD]-like receptor [NLR] family pyrin domain containing 3) gene in some patients with Schnitzler-like syndromes. Inflammasome activation is evident in patients with classical Schnitzler syndrome although no NLRP3 gene mutation is identified. Collectively, Schnitzler syndrome and Schnitzler-like syndromes represent a spectrum of IL-1 mediated adult-onset autoinflammatory diseases.