简介：AbstractBackground:Chagas disease is a parasitic disease endemic to Latin America, but it has become a disease of global concern due to migration flows. Asymptomatic carriers may host the parasite for years, without knowing they are infected. The aim of this study is to assess prevalence of Chagas disease and evaluate the participants’ level of knowledge between Latin American migrants attending a community-based screening campaign.Methods:Three community-based campaigns were performed in Alicante (Spain) in 2016, 2017 and 2018, including educational chats and blood tests for Trypanosoma cruzi serology. Participants completed a questionnaire assessing knowledge about the mechanisms of transmission, disease presentation, diagnosis, and treatment. People seropositive for T. cruzi underwent diagnostic confirmation by two different tests. Results were analyzed by multivariable logistic regression and expressed as adjusted odds ratios (aORs), adjusting for age, sex, and time in Spain.Results:A total of 596 participants were included in the study; 17% were aged under 18 years. Prevalence in adults was 11% [54/496; 95% confidence interval (CI): 8.3-14.5%] versus 0% among children. All but one case were in Bolivians. Diagnosis was independently associated with having been born in Bolivia (aOR: 102, 95% CI: 13-781) and a primary school-level education (aOR: 2.40, 95% CI: 1.14-5.06). Of 54 people diagnosed with Chagas disease (most of whom were asymptomatic), 42 (77.7%) returned to the clinic at least once, and 24 (44.4%) received treatment. Multivariable analysis showed that coming from Argentina (aOR: 13, 95% CI: 1.61-1188) or Bolivia (aOR: 1.90, 95% CI: 1.19-3.39) and having received information about Chagas disease in Spain (aOR: 4.63, 95% CI: 2.54-8.97) were associated with a good level of knowledge on the disease. Having primary level studies (aOR: 0.59, 95% CI: 0.34-0.98) and coming from Ecuador (aOR: 4.63, 95% CI: 2.52-847) were independently associated with a lower level of knowledge.Conclusions:Community-based interventions are a good strategy for diagnosing neglected diseases such as Chagas disease in non-endemic countries and for identifying and treating infected, asymptomatic individuals.

简介：AbstractBackground:Changes in thyroid hormone levels are commonly recognized characters among the elderly, which were reported to potentially influence incident frailty. Therefore, we examined the cross-sectional associations of thyroid hormones (THs) with frailty as well as the five components characterizing frailty (fatigue, resistance, ambulation, number of illnesses, and loss of weight) among the oldest-old.Methods:Four hundred and eighty-seven community-dwelling oldest-old from a local community in Haidian District, Beijing, participated in our recruitment campaign between April 2019 and May 2020. The primary outcomes were a definitive diagnosis of frailty according to the FRAIL scale (Fatigue, Resistance, Ambulation, Illnesses, Loss of weight) and a positive score for each frailty subdomain. Demographic information (age, sex, marital status, and educational status), comorbidities, and details on the participants’ lifestyles were recorded. Serum THs including free triiodothyronin (fT3), triiodothyronine (T3), free thyroxine (fT4), and thyroxine (T4) and thyroid stimulating hormone (TSH) levels were also measured at the beginning of our study. Logistic regressions were conducted to screen for potential risk factors for frailty and its subdomains.Results:Among the total 487 subjects at enrollment, 60 (12.23%) of them were diagnosed with subclinical hypothyroidism and 110 (22.59%) of the total population scored positive for frailty. Logistic regression analyses adjusted for all potential confounders, showed that frailty was significantly associated with the serum TSH concentration (odds ratio [OR]: 1.06), fT3 concentration (OR: 0.54), and subclinical hypothyroidism score (OR: 2.18). The association between fT4 and frailty was absent in our observational study. The fT3/fT4 ratio characterizing peripheral hormone conversion was also tested to be correlated with frailty.Conclusion:Subclinical hypothyroidism, higher TSH level, lower fT3 level, and decreased fT3/fT4 ratio were all associated with frailty assessed by the FRAIL scale among the community-dwelling oldest-old, suggesting a relevant role of thyroid function in aging. Future longitudinal studies are warranted to determine the casual relationship between thyroid dysfunction and frailty in the oldest-old.

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简介：正Distinguishedguests,ladiesandgentlemen,dearfriends:TodaywemeethereinpicturesqueHangzhouforthe2012UnderstandingandCooperationDialoguePartII:New-typeCommunityandHarmoniousSociety.OnbehalfoftheNationalCommitteeof

简介：1Background1.1BasicsituationofstudysiteYao’ancountyislocatedinthenorthwesternpartofcentralYunnanplateau.ItisoneoftheimportantgrainProductionbasecountiesofYunnanProvince.HanandYiarethemainethnicgroupsinthisprovince.BanliuAdministrativeVillagebelongsto...

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简介：ThedeforestationinIndonesiaisalreadyalarming.Oneofthestrategiesusedbythegovernmenttoovercomeforestdeforestationissocialforestry.ThisprogramiscalledPHBM(PengelolaanHutanBersamaMasyarakat/JointForestManagement)whichisbasicallyapartnershipprogram.Thisstudyaimsatdescribingthepartnershipprogrambetweenalocalorganization(i.e.LMDH)andagovernmentunit(i.e.RPHofPerhutani)withinthePHBMprogram.Theobjectivesofthisstudyareto(a)describethemodelofpartnershipsbetweenLMDHandRPHBesowoforsustainableforestmanagementandlocalcommunityempowerment;(b)determinethecontributionoftheforesttothenationaleconomyandruralhouseholdincome;and(c)determinetheobstaclescommonlyfoundinBesowoforestthathavetobefacedduringtheimplementationofthepartnerships.Thestudyshowsthatwithgoodpartnershipbetweenthesetwounits,theprosperityofthelocalcommunitycanbeenhancedandtheforestpreservationcanbemaintained.ThemodelofthepartnershipsinthisparticularareainIndonesiaisexpectedtobeapplicableaswellinotherruralareasinIndonesia,aswellasinotherdevelopingcountries.

简介：Soilmicrobialbiomassandcommunitystructuresarecommonlyusedasindicatorsforsoilqualityandfertility.Ainvestigationwasperformedtostudytheeffectsoflong-termnaturalrestoration,cropping,andbarefallowmanagementsonthesoilmicrobialbiomassandbacterialcommunitystructuresindepthsof0–10,20–30,and40–50cminablacksoil(Mollisol).Microbialbiomasswasestimatedfromchloroformfumigation-extraction,andbacterialcommunitystructuresweredeterminedbyanalysisof16SrDNAusingpolymerasechainreaction-denaturinggradientgelelectrophoresis(PCR-DGGE).Experimentalresultsshowedthatmicrobialbiomasssignificantlydeclinedwithsoildepthinthemanagementsofrestorationandcropping,butnotinthebarefallow.DGGEprofilesindicatedthatthebandnumberintop0–10cmsoilswaslessthanthatindepthof20–30or40–50cm.Thesesuggestedthatthemicrobialpopulationwashighbutthebacterialcommunitystructurewassimpleinthetopsoil.ClusterandprinciplecomponentanalysisbasedonDGGEbandingpatternsshowedthatthebacterialcommunitystructurewasa?ectedbysoildepthmoreprimarilythanbymanagements,andthesuccessionofbacterialcommunityasincreaseofsoildepthhasasimilartendencyinthethreemanagements.FourteenpredominatingDGGEbandswereexcisedandsequenced,inwhich6bandswereidentifiedasthetaxaofVerrucomicrobia,2bandsasActinobacteria,2bandsasα-Proteobacteria,andtheother4bandsasδ-Proteobacteria,Acidobacteria,Nitrospira,andunclassifiedbacteria.Inaddition,thesequencesof11DGGEbandswerecloselyrelatedtounculturedbacteria.Thus,thebacterialcommunitystructureinblacksoilwasstable,andthepredominatingbacterialgroupswereuncultured.

简介：AbstractBackground:Neglected tropical diseases (NTDs) affect poor populations with little or no 'political voice’ to influence control activities. While most NTDs have interventions that work, the biggest challenge remains in delivering targeted interventions to affected populations residing in areas experiencing weak health systems. Despite the upward development trends in most countries of sub-Saharan Africa (SSA), the healthcare worker to population ratio remains exceptionally low, with some areas not served at all; thus, there is a need to involve other personnel for school and community-based healthcare approaches. Nonetheless, the current community-based programs suffer from inconsistent community participation due to a lack of coordinated response, and an expanded intervention agenda that lacks context-specific solutions applicable to rural, urban, and marginalized areas.Methods:This research investigated the capacity of local communities to address the burden of NTDs. Informed by the social theory of human capability, the research collected primary qualitative data by conducting key informant interviews and focus group discussions of people infected or affected by NTDs. The interview data were collected and transcribed verbatim for thematic analysis using Nvivo version 12.Results:Our findings reveal, first, a need for intersectoral collaboration between governments and affected populations for inclusive and sustainable NTD solutions. Second, a 'bottom-up’ approach that enhances capacity building, sensitization, and behaviour change for improved uptake of NTD interventions. Third, the enforcement of Public Health Legislative Acts that mandates the reporting and treatment of NTDs such as leprosy. Fourth, the establishment of support groups and counseling services to assist persons suffering from debilitating and permanent effects of NTDs.Conclusions:Our research demonstrates the importance of human agency in encouraging new forms of participation leading to the co-production of inclusive and sustainable solutions against NTDs.

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简介：AmongthecurrentreformmeasuresundertakeninChineseK-12education,toadoptNewCurriculaandtoimproveICTapplicationinteachingarebothdecisive,however,thelackofqualifiedtrainersishandicappingtheprofessionaldevelopmentofover10millionsin-serviceteachers.OneofeChina-UKprojectsincollaborationbetweenuniversitiesfrombothsidesisdesignedtodevelopvirtuallearningcommunity(VLC)amongin-serviceteachersandexplorefrompedagogicperspectivehowtoconductVLC.Inaccordancewithreflectivelearningandcollaborativelearning,threeonlinelearningmoduleshavebeenjointlycreatedbyChineseandUKeducationalspecialists,andoneunitfromeachmodulehasbeenpilotedbyagroupofseniorteachers.Throughanalyzingtheprocessesofcoursedesignandpilot,supportedbyquantitativeandqualitativeresearchintotheexperiencesofpilotparticipants,thepaperidentifiessomecorefactorsinfluencingthequalityofVLCandsuggeststhatmoreattentionshouldbegiventotheinteractivelearningprocesswithinVLCratherthantocreatewell-structuredlearningmaterialsbeforehand.IthasalsoanalyzedVLCasapromisingapproachtosupportprofessionaldevelopmentofin-serviceteachersfromtheperspectiveofcontinuousimprovementprocess.ThereismuchtoberesearchedintotheapproachofVLC.

简介：TheCrestedIbis(NipponiaNippon)isendemictoQinlingMountainsofChinaandwasonceabundantovervastareasofnorth-eastofAsiahabitat.Duringthe20thcentury,however,thepopulationdeclinedgreatlyinnumbers.Habitatqualityusedtobethemainthreattothisspeciesbutrecentactionsbythegovernmentandwildlifeprotectionorganizationshavebroughtthisundercontrol.WiththeestablishmentofCrestedIbisNatureReserveinChina,conflictsbetweensocio-economicdevelopmentandCrestedIbisconservationhavebecomemoreacute.HowdowedealwiththerelationbetweenCrestedIbisconservationandcommunitydevelopment?Inthisstudy,theCrestedIbisNatureReserveco-managementmodelnamely'companies+farmers+NatureReserve'modelisproposedandevaluatedwithdemonstrationinvestigationmethods,includingcontinuoussix-yearfixed-sitesocio-economicdevelopmentdataofsurroundingcommunity,companysalesrevenuedataandmonitoreddataofCrestedIbisNatureReserve.Theresultsshowthatfarmers'incomeandconservationawarenessincreasedgreatlyfrom2003to2008;companysalesrevenuehasincreasedbyabout20%annuallyintherecentyears;managementlevelhasnoticeablyimprovedinNatureReserve,thescopeofCrestedIbishabitathasexpanded50hm2;chemicalcompositionofhabitatreducedyearafteryear;andthenumberofCrestedIbishadbeengrowingannually.Attheend,thesuccessofthemodelisevaluated,andproblemsinimplementationofthemodelarediscussedfromthefollowingaspects:managementsystem,co-managementconcept,economicbaseofpartners,marketingmechanism,technicalcapacityandsoon.

简介：摘要：高中英语写作的作文评价对老师来说是一项费力不讨好的工作，对学生而言，也收不到预期的效果。基于学习共同体的同伴反馈能够通过同伴之间的相互作用、相互影响的共同体，提升学生思维能力和写作能力。

简介：BackgroundCentralaorticsystolicbloodpressure(CASP)hasbeenshowntobeastrongerpredictoroftarget-organdamageandcardiovasculareventsthanbrachialsystolicbloodpressure(BSBP),buttherewasnodataaboutwhetherCASPcanpredictprolongedQRSdurationmorethanBSBP.WeexaminedtheassociationofCASPandBSBPwithQRSdurationinruralcommunityresidents.MethodsWeretrospectivelyanalyzed490ruralcommunityresidents.Standardresting12-leadECGandcentralaorticbloodpressure(CABP)weremeasurednoninvasivelyinallsubjectsatbaseline.TheQRSdurationwasequaltoormorethan120msbeingdefinedasprolongedQRSduration.ResultsTheprolongedQRSdurationgroupshowedhigherCASP(139.38±11.67vs.135.36±16.22,P=0.031)andBSBP(136.03±6.74vs.124.44±13.01,P<0.001)ascomparedwithcontrols.MultivariatelinearregressionanalysisshowedthatCASP,BSBPandheartratewereindependentlyaffectingQRSduration.LogisticregressionanalysesshowedthatCASP(OR1.057,95%CI:1.027,1.088,P<0.001)andBSBP(OR1.056,95%CI:1.027,1.086,P=0.032)wereindependentpredictorsofprolongedQRSdurationafteradjustmentforage,sex,bodymassindex,heartrate.CASPhadabetterpredictivevalueforprolongedQRSdurationthan(AUC:0.793vs.0.601,P<0.001)BSBP.ConclusionsOurfindingsdemonstratethatbothCASPandBSBParerisksforprolongedQRSduration,butCASPcanpredictprolongedQRSdurationbetterthanBSBP.

简介：TheYoungWomen’sChristianAssociation（YWCA）isawomen’sorganizationforsocialservicesthatemergedinmid-19thcenturyinthecontextofBritain’sIndustrialRevolution.BasedinGeneva,Switzerland,itisrepresentedin125countriesandregionsaroundtheglobewithamembershipofmorethan25million.TheYWCAisinconsultativestatuswiththeUNEconomicandSocialCouncilwithpermanent

简介：Background:Improvedunderstandingoftheprocessesshapingtheassemblyoftropicaltreecommunitiesiscrucialforgaininginsightsintotheevolutionofforestcommunitiesandbiologicaldiversity.Theclimateisthoughttobethefirstorderdeterminantofabundanceanddistributionpatternsoftreespecieswithcontrastingtraitssuchasevergreenanddeciduousleafphenology.However,therelativeroleofneutral,andniche-basedprocessesintheevolutionofthesepatternsremainpoorlyunderstood.Methods:Here,weperformanintegratedanalysisofthedataontreespeciesabundance,functionaltraitsandcommunityphylogenyfromanetworkof96forestplots,each1hainsize,distributedalongabroadenvironmentalgradientinthecentralWesternGhats,India.Then,wedeterminetherelativeimportanceofvariousprocessinassemblyandstructuringoftropicalforestcommunitieswithevergreenanddeciduousleafphenology.Results:Thedeciduousleafphenologicaltraithasrepeatedlyevolvedamongmultipledistantlyrelatedlineages.Treecommunitiesindrydeciduousforestswerephylogeneticallyclusteredandshowedalowrangeandvarianceof.functionaltraitsrelatedtolightharvesting,reproduction,andgrowthsuggestingniche-basedprocessessuchasenvironmentalfilteringplayavitalroleintheassemblyoftreecommunitiesintheseforests.Theexternalfactorssuchashuman-mediateddisturbancealsosignificantly,buttoalesserextent,influencesthespeciesandphylogeneticturnover.Conclusions:ThesefindingsrevealedthattheenvironmentalfilteringplaysasignificantroleinassemblyoftreecommunitiesinthebiologicallydiversetropicalforestsintheWesternGhatsbiodiversityhotspot.

简介：Thewholeyear＇sworkdependsonagoodstartinspring.On9to10April2018,thehistoriccityXi＇anwitnessedthestagingoftheFirstPeople＇sForumofShanghaiCooperationOrganization（SCO）.TheforumwasjointlystagedbyChinaNGONetworkforInternationalExchangesandthePeople＇sGovernmentofShaanxiProvince,inanaimtocontributepeople＇swisdomtotheShanghaiCooperationOrganizationQingdaoSummitwhichwillbeheldinJune2018bycollectingpeople＇swits,reflectingpeople＇swishes,buildingconsensusamongthepeople.

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简介：Objective:Therandomizedcontrolledtrial(ClinicalTrials.govidentifierNCT02990741)willinvestigatewhethermorefrequentelectrocardiographic(ECG)recordingsandanalyseswithanautomatedECGsystemwouldimprovedetectionofatrialfibrillationcomparedwithasingleannualECGscreeninelderlyChineseincommunityhealthcenters.Design:Menandwomen(≥65years)willberandomizedintointensive(n=3500)andusual(n=3500)screeninggroups,andwithintheintensivescreeninggroupintointensivescreening(n=2625)andmoreintensivescreening(n=875)subgroups.ECGrecordingswillbeperformedwithanautomatedECGanalysissystem(AliveCorheartmonitor)at1yearintheusualscreeninggroup,at3,6,9,and12monthsintheintensivescreeningsubgroup,andat1,2,3,and4weeksand3,6,9,and12monthsinthemoreintensivescreeningsubgroup.Theprimaryoutcomeisthedetectionrateofatrialfibrillationbetweentheusualscreeninggroupandtheintensivescreeninggroup.Samplesizeestimationwasbasedonaprojecteddetectionrateofatrialfibrillationof2.0%byasingleECGrecordingat12months,animprovementof50%withmorefrequentECGrecordings,α=0.05,powerof80%,andaone-sidedtest.Conclusions:ThetrialwillprovideevidenceontheclinicaleffectivenessofmorefrequentECGrecordingsbyahandheldautomatedanalysissysteminthedetectionofatrialfibrillation.

简介：【摘要】“和而不同”思想在中国已有两千多年的历史，就是在尊重客观规律的基础上，各个元素发挥不同的作用，协调发展，已实现整体上的和谐。“和而不同”思想不仅是中国传统文化的重要组成部分，也是人类命运共同体发展观的思想来源之一。作为深受中国传统文化影响的东北亚地区，“和而不同”思想也很有影响力。东北亚命运共同体的目标是实现东北亚地区的和谐，但当前东北亚国家之间存在诸多差异，中日韩之间的合作长期存在着“政冷经热”的现象。构建东北亚命运共同体需要协调这些差异，以实现和谐。这些问题在西方的“二元对立”的框架难以解决。而东方的“和而不同”的思想对于调和内部矛盾和差异，构建以“和”为目标的东北亚命运共同体具有重大的启示意义。