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简介：Primaryesophagealadenocarcinoma(PEAC)isararemalignantdiseaseofesophagus.Becauseofitslowerincidence,theknowledgeaboutitislimitedandtherearesomeproblemsrequiringfurtherstudy.Duringrecent30years,106patientswithPEAChadbeentfeatedsurgicallyinourdepartment...

简介：Cardiovasculardisease(CVD)istheleadingcauseofdeathworldwide.ThisarticlefocusesoncurrentguidelinesfortheprimarypreventionofCVDandaddressesmanagementofkeyriskfactors.Dietarymodification,weightloss,exercise,andtobaccousecessationarespecificareaswherefocusedeffortscansuccessfullyreduceCVDriskonbothanindividualandasocietallevel.Specificareasrequiringmanagementincludedyslipidemia,hypertension,physicalactivity,diabetes,aspirinuse,andalcoholintake.Thesepreventiveeffortshavemajorpublichealthimplications.Astheglobalpopulationcontinuestogrow,healthcareexpenditureswillalsorise,withthepotentialtoeventuallyoverwhelmthehealthcaresystem.ThereforeitisimperativetoapplyourcollectiveeffortsonCVDpreventiontoimprovethecardiovascularhealthofindividuals,communities,andnations.

简介：我们给更有效的标准描述主要理想或主要的理想。进一步，我们获得理想在从Gr的真实的地里主要或主要的必要、足够的条件?bner底直接。

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简介：ＩＤｅｐａｒｔｍｅｎｔｏｆＴｈｏｒａｃｉｃ＆ＣａｒｄｉｏｖａｓｃｕｌａｒＳｕｒｇｅｒｙ，ＦｉｒｓｔＵｎｉｖｅｒｓｉｔｙＨｏｓｐｉｔａｌ，ＷｅｓｔＣｈｉｎａＵｎｉｖｅｒｓｉｔｙｏｆＭｅｄｉｃａｌＳｃｉｅｎｃｅｓ，Ｃｈｅｎｇｄｕ，Ｓｉｃｈｕａｎ６１００４...

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简介：ＤＩＡＧＮＯＳＩＳＡＮＤＴＲＥＡＴＭＥＮＴＯＦＭＵＬＴＩＰＬＥＰＲＩＭＡＲＹＣＡＲＣＩＮＯＭＡＳＺｈａｎｇＳｈｕａｎｇｍｉｎ张双民ＭａＳｏｎｇｚｈａｎｇ马颂章ＹａｎｇＤａｌａｉ杨大来ＣｈｅｎＳｈｕｇｕａｎｇ陈曙光ＹａｎｇＣｈｕｎｍｉｎｇ杨春明Ｓｏｎ...

简介：AbstractPrimary aldosteronism (PA) is a common form of endocrine hypertension. The diagnostic process of PA includes a screening test, confirmatory test, and subtype classification. In this review, we have summarized the latest advances in the diagnosis of PA with regard to screening and confirmatory tests and provided some recommendations to improve clinical practice.

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简介：AIM:Toevaluatewhetherthelevelofthrombospondin-1(TSP-1)inaqueoushumorcanpredicttheprognosisoftrabeculectomyinpatientswithprimaryangle-closureglaucoma(PACG).METHODS:Thiscase-controlstudyinvolved26patientswithPACGwhoexperiencedafailedtrabeculectomy(casegroup)and78age-andsex-matchedpatientswithPACGwhounderwentsuccessfultrabeculectomy(controlgroup).AqueoushumorwascollectedatthetimeoftrabeculectomyandtestedforTSP-1andTGF-β2levelswithanenzyme-linkedimmunosorbentassaymethod.Logisticregressionmodelingwasusedtoassesstheriskfactorsforfailedtrabeculectomy.RESULTS:ThemeanTSP-1aqueousconcentrationsweresignificantlyhigherinthecasegroup(20.67±9.79ng/mL)thanthecontrolgroup(5.17±2.29ng/mL)(P<0.001).Thetransforminggrowthfactor-β2(TGF-β2)aqueousconcentrationsweresignificantlydifferentbetweenthecaseandcontrolgroup,at3633.25and1090.24pg/mL,respectively(P<0.001).LogisticregressionanalysisrevealedTSP-1levelasanindependentriskfactorforafailedtrabeculectomy(OR=3.540;95%CI=1.092-11.482).CONCLUSION:TheaqueoushumorTSP-1andTGF-β2levelsarehigherinPACGeyeswithfailedtrabeculectomythanwithsuccessfultrabeculectomyatoneyear.TheaqueoushumorTSP-1levelisanindependentriskfactorassociatedwithfailedtrabeculectomy.

简介：IntroductionAsoneofthemostfrequentlydiagnoseddevastatingdiseases,liverfailureisresponsibleforapproximatelytwomilliondeathsannuallyworldwidewithpoorprognosis1.Althoughlivertransplantationhasbeendevelopedforthemosteffectivetreatmentforliverfailure,itisfarfromdemandsforpatientsduetotheshortageofhigh-qualitydonorliversandexpensivetreatmentcosts.Currently,withthedevelopmentofcelltherapy,celltransplantationsincludingprimaryhumanhepatocytes(PHHs),humanhepatocyte-likecells(HLCs)andliverorganoidsareemergingasgreatpotentialtoolstoalleviatethisgrowingburden.

简介：客观：为王牌探索起作用的指示和主要全部的新潮的关节造形术的起作用的方法平坦骨折并且观察临床的药品effect.Methods：我们回顾地总结了并且分析创伤的条件，破裂类型，复杂并发症，起作用的时间，起作用的技术，和11patients的短期的药品效果(10男性和1女性，与42的吝啬的年龄。4年)与王牌平坦骨折经历了主要全部的新潮的关节造形术。结果；病人被跟随在上面为6-45月(吝啬的=28月)。他们手术后的新潮的关节的普通哈里斯分数是78。结论：指示的Understrict控制，有平坦骨折可以经历的王牌的病人主要全部的新潮的关节造形术，而是稳定的王牌平坦部件应该被做。

简介：Thisisapicturesqueherders'village,flankedbyhighmountainsandariver.Onthewesternslopegrowpinetrees,whilegrasslandscovertheslopetotheeast.TheofficeoftheTobatownshipgovernmentsitsinthegullybetweenthem.

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简介：Themainresultsofthispaperarestatedasfollows.LetRbeanorderringinthesemi-primaryringQ.SupposethatRsatisfiesthemaximalconditionfornilrightidealsofR,Thenwehave(i)ifanidealIofRhasafinitelengthasrightR-module,thenIalsohasafinitelengthasleftR-module;(ii)denotebyA(R)theArtinianradicalofR,andNthenilradicalofR,thenA(R)+N/N=A(R/N),ifRsatisfiesthecommutativecondi-tiononthezeroproductofprimeidealsofB.

简介：31aiscontributiondiscussestheuseofstatins(HMG-CoAreductaseinhibitors),aspirinandantihypertensivedrugsinsecondaryandprimarypreventionofcoronaryheartdisease(CHD),focusingontherationaleforandpracticalaspectsofCI-IDriskassessmentintargetingthesetreatments.

简介：ＡＣＡＳＥＲＥＰＯＲＴＯＦＰＲＩＭＡＲＹＳＱＵＡＭＯＵＳＣＡＲＣＩＮＯＭＡＯＦＴＨＥＥＮＤＯＭＥＴＲＩＵＭＨｅＷｅｎｃｕｉ何文翠；ＷｕＪｉｎｇ吴静；ＣｈａｎｇＪｉｅ唱捷；（ＴｈｅＳｅｃｏｎｄＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌ，Ｘｉ’ａｎＭｅｄｉｃａ...

简介：AbstractImportance:Extensive population-based studies have explored the prevalence of primary hypertension (HTN) in children and adolescents. However, there is little published data on the characteristics of different types of pediatric HTN and the causes of secondary HTN.Objective:To investigate the characteristics of different types of pediatric HTN and the causes of secondary HTN in a hospital setting.Methods:The study cohort comprised pediatric inpatients (<18 years of age) discharged with a diagnosis of HTN from Beijing Children’s Hospital during 2015-2020. Pediatric patients with HTN were allocated to secondary and primary HTN groups on the basis of comprehensive analyses of their diagnoses, family history of HTN, and findings on physical examination, as documented in their medical records. The Mann-Whitney U test, χ2 and Fisher’s exact test were used to assess differences in characteristics of patients with different HTN types and causes of secondary HTN.Results:Data of 1470 inpatients with HTN from 18 clinical departments were included in the analysis. Among them, 458 (31.2%) had primary HTN, and 1012 (68.8%) had secondary HTN. Compared with patients had primary HTN, children with secondary HTN were younger and had lower body mass indexes and longer lengths of stay. Moreover, children with primary HTN had mostly been managed by the Endocrinology and Cardiology Departments, 75.8% of them having obesity-related comorbidities. In contrast, most patients with secondary HTN had been managed by the Nephrology Department, renal diseases being the leading cause of their HTN (46.3%).Interpretation:Secondary HTN is more common than primary HTN in pediatric clinical settings, renal diseases being the leading cause of secondary HTN.