简介：AIM:ToobtaininformationontheprevailingpracticepatternsofglaucomaspecialistsinIndia.METHODS:GlaucomaspecialistsattendingtheAnnualConferenceoftheGlaucomaSocietyofIndia(GSI)weresurveyed.Thissurvey,conductedin2013,wasbasedonaninteractiveaudienceresponsesystem.RESULTS:Theinformationwasobtainedfrom146glaucomaspecialists.Approximatelyhalf(n=83;57%)had≥10yofexperienceinmanagingglaucomaandwereininstitutionalpractice(n=74,51%).Goldmannapplanationtonometrywaspreferredby103(72%)specialistswhilstn=25(17.4%)usednon-contacttonometer.Indentationgonioscopywasfavouredbytwo-thirds(n=90,66%)whereasstereoscopicopticdiscexaminationandvisualfieldsusingHumphreyperimeterwasperformedbyamajorityofthespecialistssurveyed(n=115,86%andn=114;83%respectively).Nearlythreequarterspecialists(n=96;72%)preferredopticalcoherencetomographyforimaging.Theprimarychoicefortreatmentofangleclosurediseaseandprimaryopenangleglaucomawaslaser(iridotomy,n=117;93%)andmedicalmanagement(prostaglandinanalogue,n=104;78%),respectively.Approximatelyonlyathirdofthespecialistssurveyed(n=37;28%)wereperformingbothtrabeculectomyandimplantationofaglaucomadrainagedeviceandabouthalf(n=64;47%)werenotoperatingoncongenitalglaucomaatall.CONCLUSION:Thissurveyhasfoundconformancewithpreferredpracticepatternsinseveralareasofdiagnosisandmanagementofglaucoma,buttherewasdiversityinafewareas.TheinformationisasignificantsteptowardsimprovementofglaucomacareinIndia,includingplanningforfuturestrategies.

简介：AIM:Toevaluatewhetherthelevelofthrombospondin-1(TSP-1)inaqueoushumorcanpredicttheprognosisoftrabeculectomyinpatientswithprimaryangle-closureglaucoma(PACG).METHODS:Thiscase-controlstudyinvolved26patientswithPACGwhoexperiencedafailedtrabeculectomy(casegroup)and78age-andsex-matchedpatientswithPACGwhounderwentsuccessfultrabeculectomy(controlgroup).AqueoushumorwascollectedatthetimeoftrabeculectomyandtestedforTSP-1andTGF-β2levelswithanenzyme-linkedimmunosorbentassaymethod.Logisticregressionmodelingwasusedtoassesstheriskfactorsforfailedtrabeculectomy.RESULTS:ThemeanTSP-1aqueousconcentrationsweresignificantlyhigherinthecasegroup(20.67±9.79ng/mL)thanthecontrolgroup(5.17±2.29ng/mL)(P<0.001).Thetransforminggrowthfactor-β2(TGF-β2)aqueousconcentrationsweresignificantlydifferentbetweenthecaseandcontrolgroup,at3633.25and1090.24pg/mL,respectively(P<0.001).LogisticregressionanalysisrevealedTSP-1levelasanindependentriskfactorforafailedtrabeculectomy(OR=3.540;95%CI=1.092-11.482).CONCLUSION:TheaqueoushumorTSP-1andTGF-β2levelsarehigherinPACGeyeswithfailedtrabeculectomythanwithsuccessfultrabeculectomyatoneyear.TheaqueoushumorTSP-1levelisanindependentriskfactorassociatedwithfailedtrabeculectomy.

简介：Introduction:Frequencydoublingtechnology(FDT)providesascreeningprogramforthedetectionofglaucomatousopticnervedamage.Theexaminationtimeusingthisprogramisveryshort,lessthanoneminutepereye.High-passresolutionperime-try(HRP)isknowntobesensitiveforearlyglaucomadamageandhasbeenreportedtodetectchangeearlier,thanconvention-

简介：Purpose:Tostudythecorrelationbetweenfunctionalandstructurallossinchronicglaucoma,asdetectedbyFrequencyDoublingTechnology(FDT)andHeilderbergRetinaTomograph(HRT).MaterialandMethods:60eyesof60patientswitheitherocularhypertensionorchronicopen-angleglaucomaunderwentvisualfieldtestingwithbothstandardautomated

简介：为了比较在在medication.METHODSA上有选择激光trabeculoplasty(SLT)和那些的病人之间的生活和治疗满足的质量，收到了SLT和用反绿内障药继续的一个控制组的143个绿内障病人上的未来的临床的试用被进行。眼泪分散时间(，但是)，标点角膜炎，对帮助的需要，人工的眼泪的使用和intraocular压力(IOP)的治疗满足调查在基线被测量，6并且12mo.RESULTSSLT能减少从1.56需要的药的吝啬的数字

简介：AIM:Todescribetheresultsof5consecutivecasesofclearlensextractioninangleclosurepatientsforthetreatmentofelevatedintraocularpressure(IOP).·METHODS:Retrospectiveobservationalcaseseries.Allangleclosurepatientswereontwoormoretopicalglaucomamedicationsandhadpriorlaseriridotomy.Eyesunderwentclearlensextractionbyphacoemu-lsificationwithintraocularlensimplantation.·RESULTS:Allfivepatientsinthiscaseseriescarriedthediagnosisofangle-closureglaucomaandhaduncontrolledIOPpriortosurgerydespitetopicalmedications.AfterclearlensextractionthreeofthecaseshadgoodIOPcontrol(IOP<22mmHg)withouttheneedfortopicalmedications.InonecasetheIOPwasbettercontrolledaftersurgery,however,topicalmedicationswererequired.ThedesiredIOPwasnotmetinonecasedespiterestartingmaximumtopicaltherapy.·CONCLUSION:Thiscaseseriessuggeststhattheremaybearolefortherapeuticclearlensextractioninselectcasesofangle-closureglaucoma.

简介：

简介：AIM:ToevaluatetheoutcomesofAhmedglaucomavalve(AGV)implantationsurgeryforrefractoryglaucoma.METHODS:Thisone-armedhistoricalcohortstudywasconductedin2011.Refractoryglaucomawasdefinedaseyeswithanintraocularpressure(IOP)greaterthan21mmHgwithmaximallytoleratedglaucomamedications,failedsurgeries,orboth.ForalleyeswithrefractoryglaucomathatunderwentAGVimplantation,datawerecollectedonIOP,thebestcorrectedvisualacuity(BCVA)andglaucomamedicationspreoperativelyand4,6,12,24and56wkpostoperatively.LogarithmvaluesofIOPwerecalculatedandcompared.RESULTS:Thestudygroupwascomprisedof30patients(30eyes,16malesand14females)withrefractoryglaucoma.MeanpreoperativeIOPwas39.3±13.8mmHg.PostoperativemeanIOPwas15.7±7.1mmHg,19.6±12.8mmHgand13.9±14.2mmHgat12,24and56wkrespectively.BCVAwas≥6/60in11eyespreoperatively,andfiveeyeshadBCVA≥6/60at56wkpostoperatively.Preoperatively,morethanfourmedicationswereusedtotreatglaucomain21eyes.At12wkpostoperatively,nomedicationswererequiredtocontrolIOPin20eyes.At56wkpostoperatively,atleastonemedicationwasrequiredtocontrolIOPin10eyes.Overtheentirefollowupperiod,foureyesweretreatedwithyttriumaluminiumgarnet(YAG)laserand14eyesrequiredasecondsurgery.TheAGVwasremovedinfoureyes.CONCLUSION:AGVimplantationreducedIOPandthenumberofmedicationsrequiredtocontrolrefractoryglaucoma.However,therewasahigherriskofdecreasedvision.Long-termfollowupandpromptinterventionarerecommended.

简介：在场的AIMTo为过滤绿内障外科以便控制高手术后的intraocular压力(IOP)的一种新奇scleral拍动suturing技术为mitomycinC的手风琴缝术技术的.METHODSDescription扩充了trabeculectomy。在手术后的高IOP的情况下，拉缝术的环帮助在两个边上由一个平压力在scleral拍动上面上升。借助于这种技术，scleral拍动以一种手风琴方式，因此阻止的拍动阻塞和提供的足够的水的flow.RESULTSOur学习开口组与neovascular由8个病人的8只眼睛组成了绿内障。这些题目的吝啬的年龄是67.42吗？？

简介：AIM:Toestablishtheefficacyandsafetyofbimatoprost0.03%monotherapyinglaucomaandocularhypertension(OHT)patientswithinadequateintraocularpressure(IOP)oncurrenttherapy.METHODS:Pre-andpost-switchIOPswereanalyzedfor59consecutivepatientswhowereswitchedfromcurrenttherapytobimatoprostmonotherapybetween2011-2015.Demographicinformation,diagnosis,andanyadverseeventswererecorded.ChangeinIOPpost-preswitchwasanalyzedusinga2-sidedStudent'spairedt-testatthe5%significancelevel.RESULTS:TherewasastatisticallysignificantmeanreductioninIOPatthefirstfollowupvisit,whichwasmaintainedatsubsequentfollowupvisitsforpatientsregardlessofdiagnosis,orpre-switchtreatment(P<0.001).SubgroupanalysisalsodemonstratedastatisticallysignificantmeanreductioninIOPwhenlookingatOHTpatientsonly,aswellaspatientswithanydiagnosisswitchedfromlatanoprostmonotherapytobimatoprostmonotherapy(P<0.001).CONCLUSION:Thisisthelargestindependentdatasetwhichsupportsswitchingglaucomapatientswithpoorresponsetocurrenttreatmentontobimatoprostmonotherapybeforeconsideringotheradjuvantmedicalormoreinvasivetherapy.

简介：AIMTo评估Ahmed的长期的结果和复杂并发症在埃及patients.METHODSA的一个队的绿内障阀门(AGV)培植经历了AGV培植并且有5y的最小的后续的有倔强的绿内障的99个病人的124只眼睛的回顾的学习被执行。所有病人经历了完全的眼的检查和intraocular压力(IOP)在外科前并且在1d的测量，为1st月，3，在外科以后并且每年的6mo，和1y后来为5y。IOP被Goldmannapplanationtonometry或Tono钢笔测量。复杂并发症和需要的反绿内障药的数字被记录。成功被定义为不到21公里Hg与或没有反绿内障药并且没有另外的绿内障surgery.RESULTSMean年龄是的IOP23.1viewed.RESULTSSurgical指示包括了rhegmatogenous网膜的分开(n=24)，完整厚度的有斑点的洞(n=12)，糖尿病的retinopathy(n=11)，玻璃的出血(n=6)，Eales疾病(n=4)，病理学的近视相关的玻璃的floater(n=2)，和有斑点的epiretinal膜(n=2)。吝啬的后续是166.4牵敧祲刮卅?協桔???????????????挠灡?潬潴祭?????????????????????????浥瑡硯汹湩攭獯湩?€浩畭潮汦潵敲'諟Ｉ????????吗?????????????？？

简介：<正>DearSir,Weherebyreportacaseofbilateralacuteangleclosureglaucomasecondarytoasystemicdecongestantcontainingpseudoephedrinefreelyavailableoverthecounter.Acuteangleclosureglaucomaisanocularemergency.Delayedrecognitionandtreatmentinevitablyleadstopermanentvisualimpairment.Acuteangleclosureoccursasaresultofobstructiontoaqueousdrainagebyblockageofthetrabecularmeshworkbytheiris.Typicalpresentingsymptomsincludeacuteonsetofocularpain,headacheandblurredvision.Onclinicalexamination,itischaracterizedbyamarkedlyraisedIOPofabove21mmHgtogetherwith

简介：AIMTo评估β的可靠性；在试验性的绿内障model.METHODSGlaucoma老鼠的一个网膜的中心房间(RGC)标记当模特儿的-III-Tubulin蛋白质被把聚苯乙烯microbeads注入C57BL/6J老鼠的前面的房间建立，在intraocular压力(IOP)被提高以后，当时，他们的视网膜是获得的14d和28d。网膜的扁平的山和节是由fluorogold(FG)和β的双labeled；-III-Tubulin抗体或由β标记单人赛；-III-Tubulin抗体，然后，RGC被认为并且比较注射眼睛的respectively.RESULTSIOP显著地被提高并且在22.8±到达了山峰；0.7公里Hg在白天14在注射以后，然后落下到11.3±；0.7公里Hg在白天28。RGC数字由标记的FG和β数了；-III-Tubulin抗体标记是64807±；4930和64614±；5054分别地在控制组织，没有重要差别。在白天14，RGC在里面试验性的组与控制组相比显著地减少了，但是标记数的FG和β之间没有重要差别；在试验性的组或在控制组把数的任何一个标记的-III-Tubulin抗体。结果在白天是类似的28，与进一步的RGCloss.CONCLUSIONOur，结果建议β；-III-Tubulin蛋白质没被IOP举起影响并且能在绿内障的试验性的模型为RGC被用作一个可靠标记。

简介：为了在长期的绿内障patients.METHODSA评估有中央角膜的subbasal神经纤维层的眼睛的表面变化和它的关联，没有任何眼睛的问题，眼睛的表面评估的未来的比较学习为至少6mo和25个正常题目的50只眼睛在使用二的25个病人或更多的antiglaucoma药的50只眼睛被执行作为控制。评估的学习参数包括了视觉尖酸，intraocular压力，眼睛的表面评估参数[荧光黄分散时间(FTBUT)，我测试的Schirmers，眼睛的表面染色分数和眼睛的表面疾病索引分数(OSDI)]，中央角膜的感觉(CochetBonnettaesthesiometer)，由在绿内障盒子和控制组中的共焦的microscopy.RESULTSThe平均数值的中央subbasal神经纤维层密度(SBNFLD)分别地如下：OSDI分数(35.89祣潴楫敮????????????木????€???€乔????偉?‰??????????倨???‵？？

简介：Aim:ToverifywhetherpartialintraoperativeTenon'scapsuleresection(PTCR)withadjunctiveMitomycinCiseffectiveindevelopingthin,avascularblebsineyesundergoingAhmedglaucomavalveinsertionandtoassesstheefficacyandsafetyofthisprocedure.Methods:ThisstudywasconductedinfourLatinAmericacountries(Argentina,Brazil,ColombiaandPeru).AhmedglaucomavalveimplantinsertionwithPTCR(groupA)andwithoutPCTR(groupB)wasperformedinneovascular

简介：AIMTo与医学上在开的角度绿内障(OAG)或在医药treatment.METHODSThis学习是的antiglaucoma下面是主要或第二等的OAG病人的回顾的评论的眼睛的高血压(OHT)病人和OHT病人作为附属治疗估计有图案的激光trabeculoplasty(PLT)的功效和安全不受管束(18公里Hg)intraocular压力(IOP)谁经历了360浥湡？

简介：AIM:Toexaminetheassociationofgeneticpolymorphisms(-308)G/ATNFα,(+250)A/GLtα,(+36)A/GTNFR1,(+1663)A/GTNFR2withthedevelopmentofprimaryopenangleglaucoma(POAG)amongpeopleinCentralRussia.METHODS:Thestudysampleincluded443individuals,ofwhich252patientswithPOAGand191individualsinthecontrolgroup.Genotypingof(-308)G/ATNFα,(+250)A/GLtα,(+36)A/GTNFR1,(+1663)A/GTNFR2wasperformedusingpolymerasechainreaction.ThedistributionofallelesandgenotypesofthestudiedDNAmarkersinthegroupswasexaminedby2×2contingencytablesandχ2withtheYates'scorrectionforcontinuityandoddsratios(OR)with95%confidenceintervals(CI).RESULTS:Allele(-308)GTNFα(Р=0.01,OR=1.78,95%CI1.12-2.85)wasidentifiedasariskfactorforPOAG.Homozygotes(-308)AATNFαareatalowestriskfordevelopmentofthedisease(Р=0.01,OR=0.0005).ThefollowingcombinationofgeneticvariantsofcytokineswereassociatedwithareducedriskofPOAG:(+1663)ATNFR2and(+250)GLtα(OR=0.34)CONCLUSION:Geneticpolymorphisms(-308)G/ATNFα,(+250)A/GLtα,(+1663)A/GTNFR2associatedwiththedevelopmentofPOAGinthepopulationofCentralRussia.

简介：第二等的绿内障的长期的结果在回顾的学习包括了的一系列中国patients.METHODSThe与Ahmed绿内障阀门(AGV)由于眼色素层炎对待培植的AIMTo报告从经历了AGV培植的有uveitic绿内障的56个病人的67只眼睛。治疗的成功被定义为完成压力(IOP)从基线IOP在6和21公里Hg之间铺平与或没有另外的反绿内障药或最少20%减小的intraocular的病人。主要结果大小包括了IOP，在1点的绿内障药的数字，3，6，12，24，36，48并且在外科以后的60mo，外科的复杂并发症，最后的改正最好的视觉尖酸(BCVA)，吗视觉地(VF)和网膜的神经纤维层(RNFL).RESULTSThe平均数后续是53.3灡?潬桲硥獩？？

简介：AbstractBackground:Normal tension glaucoma (NTG) is a less pressure-dependent type of glaucoma with characteristic optic neuropathy. Recently, the biomechanical mechanism has been thought to account for glaucomatous optic neuropathy to some degree. We intended to compare dynamic corneal response parameters (DCRs) among patients with primary open-angle glaucoma with normal tension or hypertension and controls. The correlations between DCRs and known risk factors for glaucoma were also analyzed.Methods:In this cross-sectional study, 49 NTG subjects, 45 hypertension glaucoma (HTG) subjects, and 50 control subjects were enrolled. We compared the differences in DCRs using corneal visualization Scheimpflug technology among the NTG, HTG, and control groups. We also analyzed the correlations between DCRs and known risk factors for glaucoma (eg, central corneal thickness [CCT], intraocular pressure [IOP], etc).Results:The maximum inverse concave radius (NTG: 0.18 [0.17, 0.20] mm-1; control: 0.17 [0.16, 0.18] mm-1; P= 0.033), deformation amplitude ratio of 2 mm (DAR 2 mm, NTG: 4.87 [4.33, 5.39]; control: 4.37 [4.07, 4.88]; P < 0.001), and DAR 1 mm (NTG: 1.62 [1.58, 1.65]; control: 1.58 [1.54, 1.61]; P < 0.001) were significantly higher in NTG than in the controls. The integrated radius (IR, NTG: 8.40 ± 1.07 mm-1; HTG: 7.64 ± 1.31 mm-1; P = 0.026) and DAR 2 mm (NTG: 4.87 [4.33, 5.39]; HTG: 4.44 [4.12, 5.02]; P < 0.007) were significantly higher, whereas the stiffness parameter at the first applanation (SP-A1, NTG: 91.23 [77.45, 107.45]; HTG: 102.36 [85.77, 125.12]; P = 0.007) was lower in NTG than in HTG. There were no significant differences in the DCRs between HTG and control groups (P > 0.05). In the univariate and multivariate analyses, some of the DCRs, such as IR, were negatively correlated with CCT and IOP, whereas SP-A1 was positively correlated with CCT and IOP.Conclusions:The cornea was more deformable in NTG than in HTG or controls. There were no significant differences in corneal deformability between HTG and controls. The cornea was more deformable with the thinner cornea and lower IOP.

简介：AIM:Toevaluatetheefficacyandsafetyoftrabeculectomy,phacotrabeculectomyplusintraocularlensimplantation(phacotrab+IOLgroup)andphacoemulsificationwithIOL(phaco+IOL)inprimaryangle-closureglaucoma(PACG).METHODS:Itwasasystematicreviewandmeta-analysis,randomizedcontrolledtrials(RCT)andclinicalcontrolledtrials(CCT)werecollectedthroughelectronicsearchesoftheCochraneLibrary,PubMed,EMbase,WanfangDatabaseonline,ChinesejournalFull-textDatabase,ChineseScientificJournalsFull-textDatabase(fromthedateofbuildingthedatabasetoOctober2010)Wealsocheckedthebibliographiesofretrievedarticles.Alltherelateddatathatmatchedourstandardswereabstracted.ThequalityofincludedtrialswasevaluatedaccordingtotheDutchCochraneCentre.RevMan5.0softwarewasusedforMeta-analysis.RESULTS:Atotalof5RCTand11CCTinvolving1495eyeswereincluded.Theresultsofmeta-analysisshowedthatphacotrab+IOLgroupwassuperiorthantrabeculectomy(trabgroup)(MD-3.93,95%CI[-7.31,-0.54])whichwasalsosuperiorthanphaco+IOLgroup(MD0.52,95%CI[0.10,0.95])indecreasingIntraocularPressure(IOP).Phacotrabgroup(MD-1.45,95%CI[-1.68,-1.22])andphacogroup(MD-1.12,95%CI[-1.87,-0.37])arebothdeeperthantrabgroupintheanteriorchamberdepth.Inincreasingthecoefficientofoutflowfacilityofaqueoushumor(Cvalues)therewasnostatisticaldifferenceinthethreegroups.Andtherewasnostatisticaldifferencebetweenphacotrabgroupsandphacogroupsinvisualacuitybutphacotrabgroupwassuperiorthanphacogroup(MD1.07,95%CI[0.73,1.40])intheuseofIOP-loweringdrugs.Therewasnostatisticaldifferenceamongthreegroups.CONCLUSION:Currentevidencesuggeststhatphacotrab+IOLgroupwassuperiorthantrabgroupwhichwasalsosuperiorthanphaco+IOLgroupindecreasingIOP.Phacotrabgroupandphacogrouparebothdeeperthantrabgroupintheanteriorchamberdepth.PhacotrabgroupwassuperiorthanphacogroupintheuseofIOP-loweringdrugs.