简介：AbstractMonkeypox has a very prominent regional epidemic. It has been confined to Western and Central African countries. Sporadic cases found in countries outside Africa generally have a history of sojourn in endemic areas. However, the recent multinational outbreak of monkeypox cases in Europe in early May 2022 has revealed a changing epidemiological trend, those confirmed cases had no sojourn history in endemic areas and with a high proportion of cases involving men who have sex with men (MSM). Among the MSM cases, many of them presented atypical clinical manifestations of monkeypox and with other sexually transmitted diseases co-infection. Combined with the high social interactivity in this community, there is likely a higher risk of monkeypox transmission in this population. Establishing an infectious disease surveillance system, maintaining highly vigilant regarding the transmission of monkeypox in MSM, and responding promptly are necessary and effective measures to contain the outbreak.

简介：Objectives:TodescribeandanalyzeHIV/AIDS/STD-relatedhighriskbehaviorsandaffectingfactorsofmenwhohavesexwithmen(MSM)inmainlandChina~Methods:426self-administeredorinterview-basedquestionnairescollectedfromMSMwereanalyzedwithSPSSorSASSystems.Results:OftheMSM,four-fifthshadengagedinoral-genitalintercourse,abouthalfhadengagedinanalintercourse,andinthepastyearmorethantwo-fifthshadcasualsexualpartner(s).Veryfewmaintainedmonogamoussexualrelationships,andnearlyhalfalsohadintercoursewithwomen.Onefourthhadpreviouslybeendiagnosedwithavenerealdiseases.OneHIV+individualwasfoundamongthe40whoreportedhavingbeentestedforHIV.Onlytwomenconsistentlyusedcondomsamongtheone-thirdwhohadeverusedcondoms,despitealmostuniversalknowledgeofHIVanditstransmission.Conclusions:MSMinmainlandChinaareverysexuallyactive,highlightingthepossibilityofaseriousHIVepidemicthatmaybedirectlyspreadtothefemalepopulation.However,AIDSinterventionstargetingMSMfacesevereobstructionsresultingfromculturalbiasandotherfactors.

简介：AbstractBackground:Sexual transmission among men who have sex with men (MSM) is the dominant route of HIV transmission in China. Extensive use of geosocial networking (GSN) smartphone application (app) has dramatically changed the pattern of sexual behaviors and HIV risk among MSM, but data on HIV incidence and the changing risk behaviors of GSN app-using MSM are limited. We aims to assess the HIV incidence and its correlates among gay GSN app-using MSM in China.Methods:We constructed an open cohort which was initiated and maintained using a GSN app to assess the HIV incidence among app-using MSM, recruited from June 2017 to December 2018. MSM completed an online questionnaire on their sociodemographic characteristics, sexual behaviors, recreational drug use and sexually transmitted infections status. Then each man had an HIV test, and those tested negatives were enrolled into the cohort. Participants completed follow-ups with additional HIV tests though the app during the study period, and were censored at HIV seroconversion or study end date. HIV incidence was calculated by dividing the sum of observed HIV seroconversions by the observed person-time. Univariate (Chi-square test and Fisher’s exact test) and multivariate (proportional hazards regression) analyses were used to examine correlates of HIV incidence.Results:A total of 6957 HIV negative MSM were enrolled in the open cohort, 37 seroconversions occurred among 1937 men contributing 1065 observed person-years: HIV incidence was 3.47 per 100 person-years [95% confidence interval (CI): 2.37-4.57]. More than five sexual partners [hazard ratio (HR) = 2.65, 95% CI: 1.04-6.67], and sex with HIV positive partners (HR = 3.82, 95% CI: 1.16-12.64) in the preceding six months were positively associated with HIV seroconversion. Consistent condom use for anal sex (HR = 0.27, 95% CI: 0.07-0.96), and reporting insertive anal sex only (HR = 0.23, 95% CI: 0.08-0.62) in the preceding six months were protective factors for HIV seroconversion.Conclusions:Tailored interventions targeting app-using MSM are urgently needed given their high risk of HIV. As a new tool for accessing MSM at higher HIV risk, GSN smartphone app could play an important role in HIV research among MSM.

简介：AbstractBackground:Human immunodeficiency virus (HIV) prevalence among student men who have sex with men (MSM) in college is more than 5.0% and keeps on increasing in China. This study aims to clarify the proportion of HIV recent infection, its propeller and the source among college student MSM.Methods:We conducted a multicenter cross-sectional study in seven major Chinese cities during 2012-2013. HIV recent infections (≤168 days) and incidence was measured and estimated by BED HIV-1 capture enzyme immunoassay (BED-CEIA) testing strategy. HIV-related behaviors and transmitted drug resistance (TDR) were investigated and compared between the college student MSM, < 25-year-old non-student youth MSM (NSYM), and ≥25-year-old non-student non-youth MSM (NSNYM), using structured survey, and analyses of drug resistance.Results:Overall, 4496 (4496/4526, 99.3%) were eligible for enrollment, comprising 565 college student MSM, 1094 NSYM, and 2837 NSNYM. The proportion of HIV recent infection were 70.3% (26/37), 50.8% (65/128) and 35.1% (95/271), the HIV incidence rate were 10.0 (95% CI: 6.2-13.9)/100 person-year (PY), 12.9 (95% CI: 9.8-16.1 )/100PY, 6.8 (95% CI: 5.4-8.2)/100 PY, and TDR prevalences were 7.4% (2/27), 2.0%, (2/98) and 4.9% (11/226), among student MSM, NSYM, and NSNYM, respectively. Among HIV positive student MSM with age <21 years, the proportion of HIV recent infection is 90.9% (10/11). Factors independently associated with HIV recent infection in student MSM was usage of recreational drug in the past 6 months (adjusted odds ratio [aOR]: 2.5; 95% CI: 1.0-5.8).Conclusions:College student MSM had higher proportion of HIV recent infection and TDR than the youth and older MSM in China during 2012-2013. The HIV infections were more likely to happen during the early year of college life among student MSM.

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简介：良性的prostatic增生(BPH)是最普通的医药条件在之一中年并且老人。这研究在中国的变老的男人口调查了在性别荷尔蒙的浆液层次和BPH的措施之间的关系。前列腺症状作为为人≥屏蔽节目的免费健康的部分被估计；40岁。考试包括了数字直肠的检查，前列腺特定的抗原铺平的浆液的决心，国际前列腺症状分数(IPSS)和transrectalultrasonography。全部的睾丸激素(TT)的浆液层次，性别荷尔蒙绑定血球素(SHBG)，免费睾丸激素(英尺)，luteinizing荷尔蒙(LH)，刺激滤泡的荷尔蒙(FSH)，催乳激素(PRL)和estradiol(E2)被评估。这些人也完成了一张健康和人口分布问询表并且收到了详细物理考试。最后的学习人口与58.9年的吝啬的年龄由949个人组成了。皮尔森关联分析显示除了TT，在所有性别荷尔蒙的年龄和层次之间，并且在年龄和前列腺体积之间有重要关联(PV；r=0.243；P<；0.01)或IPSS(r=0.263；P<；0.01)。另外的重要关联在IPSS和LH的浆液层次之间被发现(r=0.112；P<；0.01)并且FSH(r=0.074；P<；0.05)，但是在性别荷尔蒙层次和PV之间没有重要关联。Multivariate线性回归分析与PV显示出在年龄和身体团索引(BMI)之间的重要关联(P<；0.0001)。另外，与IPSS在年龄和PV之间有重要关联(P<；0.0001)。浆液性别荷尔蒙层次没与PV或IPSS相关。在使人变老的BPH的措施上的内分泌的变化的效果要求进一步的调查在纵并且与BPH的所有严厉包括病人的multicenter研究。

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简介：KTM的"ReadyToRace"精神KTM公司创建于1953年5月25日,总部位于奥地利的Mattighofen,在全球向来以开发制造性能卓越的越野及全功能摩托车著称,目前是欧洲第二大摩托车生产商。在越野摩托运动领域,KTM的霸主地位无人撼动,其公司车队及车手在全球所获得的赛事世界冠军已超过百个。值得一提的是,KTM的Adventuret款赛车在征战达喀尔拉力赛的历史上,创造了5连冠的史无前例的辉煌!这些伟大铸就了KTM的"ReadyToRace"的品牌精神,KTM似乎就是专为竞技、速度和冒险而生。卖车?或许这才是KTM的"主营副业"。从1992年开始,KTM摩托车的销量就以每年21%的平均速度增长(这是一个多么令众多汽车厂羡慕的数字!),这使得KTM"进入汽车产销领域已经成为一个合乎逻辑的选择"。KTM公司的CEOStefanPierer宣称X-Bow出现的意义在于"让那些没有摩托车驾驶执照的群体能够体验到KTM的动力艺术"。

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简介：<正>Women,beonyourguard.Menhaveanewexcusefornotlisteningtous.Arecentstudyshowsthatmenfinditalmostimpossibletolistentowhatwomensaybecausetheirbrainscan’tdealwithfemalevoices.Apparently,whenmenlistentoothermenaboutthethingstheycareabout,theyuseonlyfrontalareaoftheirbrains.However,whentheylis-tentowomenit’sadifferentstory.Theyhavetoworkmuchharder,usingapartofthebrainthatnormallydealswithmusic.Sowhenamantellsyouyourvoiceis"musictohisears",he’sactuallytellingthetruth,thoughnotinagoodway.

简介：Symptotm:thefollowingsymptoms,volunteeredbythepatientorelicitedthroughspecificenquiry,mayindicatethepresenceofanSTI.

简介：烽烟四起，群雄争霸，亚洲杯留给国人的有喜极而润的愉悦，也有痛初肺腑的感伤，有挂胸顿足的愤慨，也有怅然若失的遗憾，但无论结果怎样，我们都已看到——中国足球在进步！

简介：AbstractBackground:The association between sex hormone-binding globulin (SHBG) and renal function has rarely been reported in men. We aimed to investigate the above association in a community-based Chinese population.Methods:A total of 5027 men were included from the survey on prevalence for metabolic diseases and risk factors, which is a population-based study conducted from 2014 to 2016 in Eastern China. The estimated glomerular filtration rate (eGFR) was calculated according to the chronic kidney disease Epidemiology Collaboration equation. Low eGFR was defined as eGFR <60 mL·min-1·1.73 m-2.Results:After adjusting for age, smoking, metabolic factors, and testosterone, through increasing quartiles of SHBG, a significantly positive association between SHBG quartiles and eGFR was detected in men (Q1 vs. Q4, β -2.53, 95% confidence interval -3.89,-1.17, Ptrend < 0.001). Compared with the highest quartile of SHBG, SHBG in the lowest quartile was associated with 96% higher odds of low eGFR (odds ratio 1.96, 95% confidence interval 1.10, 3.48) in the model after full adjustment. According to the stratified analyses, the associations between a 1-standard deviation increase in serum SHBG and the prevalence of low eGFR were significant in men aged ≥60 years old, waist circumference <90 cm, diabetes (no), hypertension (yes), dyslipidemia (no), and nonalcoholic fatty liver disease (no).Conclusions:Lower serum SHBG levels were significantly associated with lower eGFR and a higher prevalence of low eGFR in Chinese men independent of demographics, lifestyle, metabolic-related risk factors, and testosterone. Large prospective cohort and basic mechanistic studies are warranted in the future.

简介：Theprolongationoflifeexpectancyandthedrasticreductionoffertilityratearetheprimarycauseofanagingworld.Itisprojectedthattheelderly(above65)willincreasewithinthenext25yearsby82%,whereasthenewbornonlyby3%.Despitetheenormousmedicalprogressduringthepastfewdecades,thelastyearsoflifearestillaccompaniedbyincreasingillhealthanddisability.Theabilitytomaintainactiveandindependentlivingforaslongaspossibleisacrucialfactorforaginginhealthanddignity.Therefore,thepromotionofhealthyagingandthepreventionofdisabilityinmen,mustassumeacentralroleinmedicalresearchandmedicalpracticeaswellasintheformulationofnationalhealthandsocialpolicies.Effectiveprogramspromotinghealthandagingwillensureamoreefficientuseofhealthandsocialservicesandimprovethequalityoflifeinolderpersonsbyenablingthemtoremainindependentandproductive.Themostimportantanddrasticgenderdifferencesinagingarerelatedtoorgansandorsystemsdependantorinfluencedbyreproductivehormones.Indistinctiontothecourseofreproductiveaginginwomen,withtherapiddeclineinsexhormonesandexpressedbythecessationofmenses,agingmenexperienceaslowandcontinuousdeclineofhormones.Thisdeclineinendocrinefunctioninvolves:Adecreaseoftestosterone,dehydroepiandrosterone(DHEA),oestrogens,thyroidstimulatinghormone(TSH),growthhormone(GH),insulin-likegrowthfactor-1(IGF-1),andmelatonin.ThisdecreaseisconcomitantwithanincreaseofLHandFSH.Inadditionsexhormonebindingglobulin's(SHBG)increasewithageresultinginfurtherloweringtheconcentrationsoffreebiologicallyactiveandrogens.Interventionssuchashormonereplacementtherapymayprevent,delayoralleviatethedebilitatingconditionswhichmayresultfromsecondarypartialendocrinedeficiency.Primaryandsecondarypreventivestrategiessuchasthepromotionofasafeenvironment,healthylifestyleincludingp

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简介：""Mensaytheyhatetoshop,""saysZhukin,CityUniversityofNewYorkSociology(社会学)professor.""Yetwhenyouaskthemdeeperquestions,itturnsoutthattheyliketoshop.Mengenerallyliketoshopforbooks,musicandhardware.Butifyouaskthemabouttheshoppingtheydoforbooksormusic,they'llsay,'Well,that'snotshopping.That'sresearch.'""

简介：电影《大话西游》里周星驰扮演的孙悟空，在经历前世五百年和后世五百年的磨难与纠结后，幡然醒悟：“后世的至尊宝不过是前世孙悟空的倒影，自己划过的依旧是前世的轨迹。”

简介：我们比较了与长期的前列腺炎症候群(每秒字符数)联系的棒状细菌细菌的潜在的phenotypic性质，例如溶解酵素(SIL)的能分泌的禁止者和血小板microbicidal蛋白质(SIPMP)的能分泌的禁止者。一个总数110临床棒状细菌孤立与每秒字符数从健康的人和人的精液孤立的细菌被测试。SIPMP生产被禁止血小板microbicidal测试对杆菌subtilis的蛋白质(PMP)bioactivity，并且被表示为PMP的抑制的百分比杀菌活动。SIL生产被对小球菌lysodeikticus禁止溶解酵素活动测试并且每使失去活性的溶解酵素的毫升在microgram被表示。每秒字符数紧张(58.7%对19.2%)的一个显著地更高的比例与非每秒字符数紧张相比是SIPMP积极的(P<0.01)。测试的CPS紧张，77.8%与34%非每秒字符数相比是SIL积极的孤立(P<0.05)。这些结果建议例如，每秒字符数的诊断不应该完全依靠古典参数鉴定并且微生物，而是这些参数的功能的意义数必须被估计，可能由不同细菌的substrains的集中，有病原的性质的机会主义的微生物的察觉，例如到cationic抗菌剂的显著抵抗，禁止抗菌剂的肽，或能力招待防卫因素。