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简介：Withhalfacentury’svicissitudes,theformerEuropeanEconomicCommunity(theEEC)withamembershipofonlysix-France,theFederalRepublicofGermany,Italy,Luxembourg,BelgiumandtheNetherlandshasgrownintotoday's27-memberEuropeanUnionwiththemissionextendedfromonlyeconomiccooperationtoanall-encompassingcooperationinpolitical,social,judicialandsecurityfieldsandetc.Nomatterhowpeopletrytoappraiseit,thedevelopmentoftheEUanditsachievementscannotbedenied.

简介：Overthepastthreeyears,thegreatappealandbrightfutureoftheBeltandRoadInitiativehaspresentedsharpcontrastwiththetrendsemergedinsomeregions,suchaswidespreadpopulism,risingprotectionism,theawakeningthoughtofantiglobalizationandhinderedfrustratedeconomic

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简介：AbstractObjective:Alternative splicing can generate various structural and functional protein isoforms. Recently, accumulating evidence shows a relationship between alternative splicing and cancer. Cancer is a complex and chronic disease that involves malignant transformation. In this review, we consider alternative splicing events in relation to the hallmarks of cancer cells, and discuss current therapies to treat cancer-related to alternative splicing.Data sources:Data cited in this article are from the PubMed and Embase database, primarily focusing on research published from 2000 to 2018.Study selection:Articles were selected with the search terms "alternative splicing," "cancer cell," "tumor microenvironment," and "therapy."Results:Alternative splicing plays an important role in tumorigenesis, development, and escape from cell death. Taking this trait of cancer cells into consideration will allow more definite diagnoses of cancer, and allow the development of more effective medicines to intervene in cancer that could focus on controlling alternative splicing or competitively binding to the final products.Conclusions:Alternative splicing is common in cancer cells. Consideration of alternative splicing may allow different strategies for cancer therapy or the identification of novel biomarkers for cancer diagnosis.

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简介：IntroductionTheattitudestowardsforeignlearners’errorshavechangedremarkablyfromthe1960storecentyears.Intheeyesofbehaviouristsinthe1960s,errorswereconsideredterrible.Teacherstriedtostructuretheclassroomsituationsoastomakeitideallyimpossibleforstudentstomakeerrors.SincetheevolutionofChomsky’stheoryandmodernism,teachershavebeguntobelievethatcommunicationinthelanguageismoreimportantthanasterileperfectionofform.andtherefore,theyhavebecomemoretolerantofstudents’errors.Makingerrorshasbeenrecognisedmoreandmoreasinevitableandasanessentialpartoflanguagelearning.

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简介：Theobjectivesofthisresearchweretocharacterisetheclaymineralscompositionofsoil-deriveddustinNorthernChinaandtosetupamineralogicalsignaturetotracetheirorigin.MineralcompositionofaerosolparticleswasinvestigatedatAksu,Dunhuang,Yulin,TongliaoandChangwuduringanintensivefieldcampaignperiodofACE-Asia.Theresultsshowthatthekaolinite(K)tochlorite(C)ratioissensitivetotheregionaloriginofAsiandust.Westernsourceareas(representedbyAksu)displayedthelowestK/Cratioof0.3(average),whileitwasfoundtoincreaseupto0.70(average)uponmovingtowardsnorthernsourceareas(representedbyYulin).BystudyingtransporteddustinadepositionarearepresentativeoftheChineseLoessPlateau,theusefulnessoftheK/Cratio,whenassociatedwithbackair-masstrajectories,wasfoundtolieinrevealingtheoriginofthedust.ComparisonofthemineralogicaldatabetweenAsiandustandSaharadust,showsthattheK/Cratioisalsoaneffectivesignaturetoidentifythesourceareasonahemispherescale.

简介：Heterotic组理论(HGT)在支持混合玉米繁殖大约100年起了一个主要作用。HGT的基本内容和研究，和它在米饭和玉米的应用程序在这份报纸被总结。另外，为在中国繁殖的混合米饭的困难和挑战被分析，并且在由使用HGT繁殖的混合米饭的必要性和紧急被建议。

简介：磁化率(MS)是东方的最重要的指示物之一--亚洲夏季风。在这介绍了学习是从Xifeng节的一个高分辨率磁化率记录，它由第四级的loess-paleosol组成顺序和上新世红色粘土。在磁化率的变化很好与δ18在深海的沉积和格林兰的eolian流动的O记录。在Xifeng节的气候的进化后来显示出那晚第三级，东亚paleo季风的驱动力在10-ka时间规模上与太阳辐射被相关。

简介：Objective:Toprovidedetailedinformationofcoronamortisforilioinguinalapproachasananteriorapproachtotheacetabulumandpelvis.Methods:Thecourse,branchesanddistributionofthevascularconnectionbetweentheobturatorsystemandtheexternaliliacorinferiorepigastricsystemslocatedoverthesuperiorpubicramuswereobservedon50hemipelviseswithintactsofttissues.Results:Duringthedissections,72%ofthecadavericsideshadatleastonecommunicatingvesselbetweentheobturatorsystemandtheexternaliliacorinferiorepigastricsystemsonthesuperiorpubicramus.Theaveragediameteroftheconnectingvesselwas2.6mm(range,2.0-4.2mm).Itcoursedoverthesuperiorpubicramusoriliopubiceminenceverticallytoentertheobturatorforamenandexitthepelvis.Theaveragedistancefrompubicsymphysistothevascularconnectionsbetweentheobturatorandexternaliliacsystemswas52mm(range,38-68mm).Conclusions:Vascularconnectionsbetweentheobturatorsystemandtheexternaliliacorinferiorepigastricsystemswerefoundoverthesuperiorpubicramuswithahighincidence.Theyarepronetodamageduringtheilioinguinalapproachasananteriorapproachtotheacetabulumandpelvis.Thus,coronamortislocatedoverthesuperiorpubicramusdeservesgreatattentionduringtheilioinguinalapproach.

简介：基因的表示“在正确地方以内”并且在正确时间被限制，这通常被相信。这个原则长也被认为适用到免疫球蛋白(Ig)的表示B的淋巴细胞房间系。然而，增加证据证明了Ig“似非而是地”在上皮的起源的恶意的肿瘤表示了。我们在导出癌症的Ig的学习考察了最近的进步，并且也讨论了它的机制和可能的功能，试着引起到那些在免疫学和肿瘤学的领域里工作的兴趣和注意。

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