简介：Objective:Thisstudyaimstoinvestigatetheclinicopathologicsignificanceoflymphaticvesselinvasion(LVI)labeledbyD2-40monoclonalantibodyinesophagealsquamouscellcarcinoma(ESCC).Methods:ImmunohistochemicalassaywasusedtodetecttheexpressionofD2-40andLVIin107ESCCpatients.Then,thecorrelationbetweentheclinicopathologicfeatureandtheoverallsurvivaltimeofthepatientswasanalyzed.Results:Thelymphnodemetastasisrateswere70%and21%intheLVI-positiveandLVI-negativegroups,respectively.ThenodalmetastasisratewashigherintheLVI-positivegroupthanintheLVI-negativegroup.MultivariateregressionanalysisshowedthatLVIwasrelatedtonodalmetastasis(P<0.001).Themediansurvivaltimeofthepatientswas26and43monthsintheLVI-positiveandLVI-negativegroups,respectively.Althoughunivariateregressionanalysisshowedsignificantdifferencebetweenthetwogroups(P=0.014),multivariateregressionanalysisrevealedthatLVIwasnotanindependentprognosticfactorforoverallsurvivalintheESCCpatients(P=0.062).Lymphaticnodemetastasis(P=0.031),clinicalstage(P=0.019),andresidualtumor(P=0.026)weretheindependentprognosticfactors.Conclusion:LVIlabeledbyD2-40monoclonalantibodyisariskfactorpredictiveoflymphnodemetastasisinESCCpatients.

简介：Voluminousplatinum-groupmineral（PGM）inclusionsincludingerlichmanite（Os,Ru）S2,laurite（Ru,Os）S2,andirarsite（Ir,Os,Ru,Rh）AsS,aswellasnativeosmiumOs（Ir）andinclusionsofbasemetalsulphides（BMS）,includingmillerite（NiS）,heazlewoodite（Ni3S2）,covellite（CuS）anddigenite（Cu3S2）,accompaniedbynativeiron,havebeenidentifiedinchromititesoftheZedangophiolite,Tibet.ThePGMsoccurasbothinclusionsinmagnesiochromitegrainsandassmallinterstitialgranulesbetweenthem;mostarelessthan10μminsizeandvaryinshapefromeuhedraltoanhedral.Theyoccureitherassingleorcomposite（biphaseorpolyphase）grainscomposedsolelyofPGM,orPGMassociatedwithsilicategrains.Os-,Ir-,andRu-richPGMsarethecommonspeciesandPt-,Pd-,andRh-richvarietieshavenotbeenidentified.SulfurfugacityandtemperatureappeartobethemainfactorsthatcontrolledthePGEmineralogyduringcrystallizationofthehostchromititeintheuppermantle.Iftheactivityofchalcogenides（suchasS,andAs）islow,PGEclusterswillremainsuspendedinthesilicatemeltuntiltheycancoalescetoformalloys.Underappropriateconditionsof?S2and?O2,PGEalloysmightreactwiththemelttoformsulfides-sulfarsenides.Thus,wesuggestthattheOs,IrandRumetallicclustersandalloysintheZedangchromititescrystallizedfirstunderhightemperatureandlow?S2,followedbycrystallizationofsulphidesofthelaurite-erlichmanite,solid-solutionseriesasthemagmacooledand?S2increased.TheabundanceofprimaryBMSinthechromititessuggeststhat?S2reachedrelativelyhighvaluesduringthefinalstagesofmagnesiochromitecrystallization.ThediversityofthePGEminerals,incombinationwithdifferencesinthepetrologicalcharacteristicsofthemagnesiochromites,suggestdifferentdegreesofpartialmelting,perhapsatdifferentdepthsinthemantle.Theestimatedparentalmagmacompositionsuggestsformationinasuprasubductionzone

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简介：与在中间的最好、古典的剖面图Trans北方ChinaOrogen分割的邻近的Fuping和HengshanComplexesrepresents联系的Wutai建筑群，通常划分了成东方、西方的块。UnconformablyoverlyingWutaiandFuping建筑群Hutuo组在这个区域被看作最年轻的岩石地层单位并且为解释前寒武纪的历史以及theTrans北方中国造山带的全面进化重要。在这个组的沉积岩的起源的知识的缺乏妨碍了depositional和构造意义的理解。LA-ICP-MS被使用为花岗石的卵石获得U-Pb锆石年龄，Hutuo组的最低岩石层位学的岩石，它，与结合了以前的岩石层位学，geochronological，结构、变形的数据，在沉积起源和这个区域的构造进化上提供新限制。Hutuo的顺序从更低的底砾岩andvolcaniclastic岩石(Doucun亚群)向上组织范围，通过碎屑沉积物，板岩，白云石和云石(Dongye亚群)，到在顶(Guojiazhai亚群)的沙岩和集团企业。从在Doucun亚群底砾岩保存的花岗石的卵石的锆石给加权的mean~(207)在2517妈和2566妈之间的Pb/~(206)Pb年龄，它与为迟了的ArcheanWutaiGranitoids的那些一样，显示卵石从Wutai花岗石的侵入(2566-2515妈)被导出。基于新数据和以前的研究，与在Hutuo组为volcanics获得的2087±9妈的火的锆石结晶化年龄结合了，Hutuo组在在东方块的西方的边缘下面在西方的块的东方指导俯冲期间在theWutai弧后面发展了的subduction相关的制动火箭弧低岬盆环境被扔。这盆经历了长寿沉积并且最后在～1期间关上了导致了北方中国古地台的最后的合并的850妈collisional事件。

简介：Objective:Toinvestigatetheroleofintercellularadhesionmolecule-1(ICAM-1)intheaccumulationofpolymorphonuclearneutrophils(PMN)inthelungsattheearlystageofburns.Methods:Myeloperoxidasecontentinlungtissuesandbronchoalveolarlavagefluid(BALF)weredetected.ICAM-1anditsmRNAexpressioninlungtissuesweredeterminedbyimmunohistochemicalmethodandinsituhybridization.CD11b/CD18expressionontheperipheralPMNswasmeasuredbyflowcytometry.Results:ThelevelsofmyeloperoxidaseinlungtissuesandBALFafterburninjuryweremarkedlyhigherthanthoseofcontrol.ExpressionofICAM-1anditsmRNAinthelungtissuesandCD11b/CD18onperipheralPMNssurfacewassignificantlyincreasedat2,6,12,24hafterburns.Conclusions:PMNsaccumulationinthelungsisrelatedtoincreasedICAM-1expressiononpulmonarymicrovascularendothelialcellsandCD11b/CD18expressiononPMNattheearlystageofburninjury.

简介：40Ar-39ArdatingofalbitefromtheMeishanandTaocunirondepositsyieldsplateauagesof122.90±0.16Maand124.89±0.30Ma,andisochronagesof122.60±0.16Maand124.90±0.29Ma,respectively.PhlogopitefromtheZhongshan-Gushanorefieldhasaplateauageof126.7±0.17Maandanisochronageof127.21±1.63Ma.Analysisofregionalgeodynamicevolutionofthemiddle-lowerYangtzeRiverregionsuggeststhattheporphyryirondepositswereformedasaresultoflarge-scalelithospheredelaminationandstrongsinistralstrike-slipmovementoftheTanchengLujiangfaultzone.Thecopper,molybdenumandgolddepositsysteminthemiddle-lowerYangtzeRiverregionwasformedduringthestresstransitionperiodoftheeasternChinacontinent.

简介：摘要：岭南庭园建筑具有很强的包容性，在其漫长的发展历程中不断兼容并蓄，时至今日对当代建筑设计也有重要的借鉴意义。本文通过总结岭南庭园建筑包括建筑适应气候及环境、建筑融于自然、路径联系高效、空间层次丰富以及体现场所精神等四个特点，结合当代建筑的实际案例，尝试归纳总结两者间的联系、探讨岭南庭园建筑对当代建筑设计的借鉴意义。本文旨在吸收和借鉴岭南传统庭园建筑的精华，并为今后的设计提供指导意义。

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简介：EarlyPaleozoicgranodioritehasbeenidentifiedonthenorthernmarginoftheNorthChinacratonintheeastsectionofthecentral-Asianorogenicbelt,whichwaspreviouslyknownasearlyIndosinianinage.ByusingtheLA-ICP-MSmethod,theobtainedzirconU-Pbageis445.62.7Ma,whichrepresentsthecrystallizationageofthegranodiorite.Thegranodioriteneartheeastofthelarge-sizedBilihegolddepositisofthetholeiiteserieswithlowpotassium.Itisquasi-aluminousI-typegranite,enrichedinsodium(Na2O/K2O=7.299.77)andmagnesium(Mg#=0.510.67).TheΣREEvalueisrelativelylow,obviousdifferentiationisshownbetweenLREEandHREEandwithinLREE,andtheEuanomalyislowandnegative(δEu=0.740.91).Intheprimitive-mantlenormalizedspiderdiagramsoftraceelements,thegranodioriteisrelativelyrichinLREEandLILE(Ba,Sr,Th),andstronglydepletedinHFSE(Nb,Ta,TiandP),whichshowsfeaturesofsubductionzonecomponents(SZC).InthediscriminationdiagramsoftectonicsettingsofgraniteforRbvs.(Nb+Y),Rbvs.(Ya+Ta),La/Nbvs.Ba/NbandTh/Nbvs.Ba/Nb,thegranodioriteexhibitstypicalfeaturesofislandarcgranite.ThenormalizedvaluesofKandRbareextremelylow,whilethevaluesofSrandEuareveryhigh,whicharesimilartothoseofislandarcmagmathathasundergonemetasomatismoffluidfromtheoceaniccrust.ThegranodioriteisrelativelydepletedinεHf(t)(5.17.1)andlowinεHf(t)modelages(1089921Ma).IntheεHf(t)vs.age(T)diagram,thedistributionareaofthegranodioriteisaccordantwiththefieldoftheXing'anling-Mongoliaorogenicbelt,whichindicatesthatthemagmaticsourcesaremainlythemixtureofpartialmeltingofwedgedmantlesubjectedtometasomatismoffluidfromtheoceaniccrustandyoungsubstancefromthecrust.ThegranodioriteissimilartothefelsicarcmagmaintheDamaoBanner,BateObon,BoinSumandOrdorSumregions,andtheyaltogetherconstituteanearlyPaleozoicaccretionaryislandarcma

简介：在Huangling背斜位于YangtzeCraton以内的olivine-gabbroic岩石被标明日期在大约由LA-ICP-MS的857-854妈方法。岩石属于亚alkaline系列并且由辉石(35%-40%)组成，斜长石(40%-45%)，橄榄石(8%-10%)和尖晶石(3%-5%)。橄榄石有作为贵橄榄石被分类的73-83的Fo价值。辉石有FeO(6.60wt.%-8.23wt.%)的相对低内容，但是然而，高CaO(20.23wt.%-21.25wt.%)满足斜长石有高级艾尔2O3(31.78wt.%-32.37wt.%)，CaO(16.08wt.%-16.25wt.%)并且一(79-80)价值，但是低Na2O内容(1.95wt.%-2.11wt.%)。尖晶石是有MgO(13.65wt.%-13.68wt.%)的高内容的特征的magnesioferrite，FeO(23.27wt.%-23.40wt.%)和艾尔2O3(62.43wt.%-62.74wt.%)。这些矿物质的化学作文类似于在造山运动以后的环境被形成的斑粝岩岩石的那些。橄榄石斑粝岩样品有否定锆石Hf价值(-16.57吗？？

简介：Byusingthe40Ar-39ArchronologicalmethodtodateK-feldsparfromK-feldspargraniteintheQiaohuotecopperdistrict,theauthorsobtainedaplateauageof274.78±0.44Maandanisochronageof272.7±3.0Ma.BecausethereisnotectonicdeformationoverprintedorhydrothermalalterationintheK-feldspargraniteintrusionafteritsemplacement,the40Ar-39AragerepresentsthecrystallizationageofK-feldsparinK-feldspargranite,i.e.thelatecrystallizationageoftheK-feldspargraniteintrusion,whichindicatesthattheK-feldspargraniteformedintheintraplateextensionalstageduringtheEarlyPermian.Moreover,basedonthespatialrelationshipbetweentheK-feldspargraniteintrusionandcopperorebodies,variationsofcopperoregrade,REEcharacteristicsofK-feldspargraniteandcopperores,andHandOisotopiccompositionsoffluidinclusionsincopperores,themetallogenesisoftheQiaohuotecopperdepositisdirectlyrelatedtointrusiveactivitiesoftheK-feldspargranite,andthusthecrystallizationageofK-feldsparinthegraniteapproximatelyapproachesthemetallogenicepochoftheQiaohuotecopperdeposit.

简介：TheaimofthisstudyistoinvestigatecyclinE,pl6inkdaandki67aspossiblediagnosticbiomarkersforcervicalpreneoplasiausingcervicalexfoliated-cellspecimens,andevaluatethesignificanceforscreeningpatientsathighriskofdevelopingcervicalcarcinoma.TheexpressionofcyclinE,pl6inkdaandki67wasexaminatedin78cervicalexfoliatedepithelialspecimensdiagnosedasatypicalsquamouscellsofundeterminedsignificance(ASCUS)(12cases),cervicalintraepithelialneoplasia(CIN)oftype1(17cases),CIN2_3(38cases)andinvasivecarcinoma(11cases)usingimmunohistochemicalanalysis,andsimultaneously,theDNAstatusofhumanpapillomavims(HPY)type16/18wasdetectedbypolymerasechainreaction(PCR)usingtypespecificprimers,cyclinE,pl6inkdaandki67werealloverexpressedinCINsandinvasivecarcinoma,comparedwithlittleexpressioninASCUS(P<0.005).OverexpressionofcyclinEwasobservedinCIN1(94.1%,X^2=21.16,P<0.01),andp16inkdaandki67wereoverexpressedininvasivecarcinoma(100%and90.9%respectively).Thedegreeofpl6inkdaandki67expressioncorrelatedwellwiththatofepitheliallesions(P<0.005).HPV16/18infectionwasassessedinC1Nsandinvasivecarcinomasamples,andrevealedasignificantrelationshipwiththedegreeofcervicalepitheliallession.Theexpressionlevelofpl6inkdaandki67seemedmorecloselyassociatedwithHPVI6infectionthanthatofcyclinE(rs=1.0vsrs=0.4).Only1caseinCINIanddcasesinCIN2-3ofHPV18positivesamplesweredetected.Thereforenostatisticalsignificancewasfoundbystatisticalanalysis.OverexpressionofcyclinE,pl6inkdaandki67inCINsandinvasivecarcinomacellsdemonstratesthepotentialuseofcyclinE,pl6inkdaandki67asdiagnosticbiomarkersforHPV-relatedcervicalneoplasticlesions.Inaddition,thistechniquecanbeusedforscreeningpatientsathighriskofdevelopingcervicalcarcinoma.

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