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简介：闲聊其实是很好的打开话题的方式,如果你看过一部好看的电影或读过一本不错的书,你就可以和别人谈一谈。研究表明,你用自然的方式闲聊,可能会让自己变得更加快乐。下面就来看看闲聊是怎样帮助我们打开话题的。Smalltalkandchitchat1aretheshortconversationswehaveatpar-ties,whilewewaitinlineatthestoreorfamilyevents.Sometimeswe

简介：TheChinesemagazine“SmallHydropower”waslaunchedinMarch1984,andhasreceivedahugewelcomefromitsmanyreadersworldwide.

简介：【话题引入】本期的“话题写作”我们一起来“闲聊”一下【基础词汇】athand手头harmfuladj.有害的

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简介：Objective:Toexplorethereversaleffectofmifepristoneonmultidrugresistance(MDR)indrug-resistanthumanbreastcancercelllineMCF7/ADRanditsmechanisms.Methods:ExpressionofMDR1andMDR-associatedprotein(MRP)mRNAinMCF7/ADRcellswasdetectedusingreversetranscription-polymerasechainreaction(RT-PCR).WesternblottingwasusedtoassaytheproteinlevelsofP-glycoprotein(P-gp)andMRP.Intracellularrhodamine123retentionand[3H]vincristine(VCR)accumulationweremeasuredbyflowcytometryandliquidscintillationcounter,respectively.MTTreductionassaywasusedtodeterminethesensitivityofcellstotheanticanceragent,adriamycin(ADR).Additionally,aMCF7/ADRcellxenograftmodelwasestablishedtoassessthereversaleffectofmifeprisoneonMDRinMCF7/ADRcellsinvivo.Results:Miferpristonedose-dependentlydown-regulatedtheexpressionofMDR1andMRPmRNAinMCF7/ADRcells,accompaniedbyasignificantdecreaseintheproteinlevelsofP-gpandMRP.Afterexposureto5,10,and20μmol/Lmifepristone,MCF7/ADRcellsshoweda3.87-,5.81-,and7.40-foldincreaseintheaccumulationofintracellularVCR(aknownsubstrateofMRP),anda2.14-,4.39-,and5.53-foldincreaseintheretentionofintracellularrhodamine123(anindicatorofP-gpfunction),respectively.MTTanalysisshowedthatthesensitivityofMCF7/ADRcellstoADRwasenhancedby7.23-,13.62-,and20.96-foldafterincubationwithmifepristoneasabove-mentioneddosesfor96h.Invivo,mifepristoneeffectivelyrestoredthechemosensitivityofMCF7/ADRcellstoADR.After8weeksofadministrationwithADR(2mg·kg-1·d-1)aloneorincombinationwithmifepristone(50mg·kg-1·d-1),thegrowthinhibitoryrateofxenograftedtumorsinnudemicewas8.08%and37.25%,respectively.Conclusion:MifepristoneexertspotentreversaleffectsonMDRinMCF7/ADRcellsinvitroandinvivothroughdown-regulationofMDR1/P-gpandMRPexpressionandinhibitionofP-gp-andMRP-dependentdrugefflux,thusincreasing

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简介：AbstractThis review attempts to unveil the possible mechanisms underlying how gut lymph affects lung and further gives rise to acute respiratory distress syndrome, as well as potential interventional targets under the condition of ischemia-reperfusion injury. We searched electronic databases including PubMed, MEDLINE, Cochrane Central Register of Controlled Trials, Google Scholar, Web of Science, and Embase to identify relevant literatures published up to December 2019. We enrolled the literatures including the Mesh Terms of "gut lymph or intestinal lymph and acute lung injury or acute respiratory distress syndrome." Gut is considered to be the origin of systemic inflammation and the engine of multiple organ distress syndrome in the field of critical care medicine, whereas gut lymph plays a pivotal role in initiation of ischemia-reperfusion injury-induced acute respiratory distress syndrome. In fact, in the having been established pathologic model of sepsis leading to multiple organ dysfunction named by Gut Lymph theory, a variety of literatures showed the position and role of changes in gut lymph components in the initiation of systemic inflammatory response, which allows us to screen out potential intervention targets to pave the way for future clinic and basic research.

简介：Amonolithichybridfuelcell(MHFC)withanovelconfigurationwasproposedinanefforttoimprovethefuelcellperformanceduringinstantaneouspowerchanges.Amodifieddirectmethanolfuelcell(DMFC)withalayerofhydrousrutheniumdioxide(RuO2·xH2O)sandwichedbetweentheanodecatalystlayerandmembranewasusedtodemonstratetheprincipleoftheMHFC.ExperimentalresultsindicatethattheRuO2·xH2Olayerisequivalenttoaresistor-capacitortransmissionlineandfunctionssimilartoacapacitorinparallelwiththeanodeelectrode.TheimprovementindynamicresponseoftheMHFCwasexperimentallyconfirmedunderstepcurrentchangeandsquarecurrentpulseoperating.TheionicconductivityoftheRuO2·xH2Olayerwasalsoobtained.

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简介：空闲的时候人们都喜欢聊天，有时候甚至可以天南海北地聊上几个钟头。聊天的内容不受主题的限制，可以谈论天气，计划，假期，喜好，饮食等等。

简介：上班族对“五一”肯定拥有特别的好感。因为在这个日子里，终于可以将工作上的酸甜苦辣抛在脑后，尽情享受自己的节日了!那么，我们本期就来学一些与工作和“五一”相关的语句。

简介：Nigeriaisthemostpopulaousblacknationintheworld.Ithasanareaof913,072squarekilometres.Thecountrypopulationisabout120million.Therearethreemajorlanguages,Hausa,YorubaandIgbo,althoughthereisstillmorethan380dialectsinlocallanguages.TherearelargenumberofhouseholdontheAfricancontinentthatareunelectrified.InNigeriaabout70millionpeopleremainliterallyinthedarkwithoutaccesstoelectricity.Themajorityofthesenumbersareintheruralareas.Thisworkshopisaptinanumberofways.Itisajointeffortbetweengovernment,privatesector,theacademicandotherpractitionersinsmallhydropowerstation,itisalsoapromotionofbusinessandindustrialactivitiesaswellasdevelopmentofrenewableenergyresources.Iwishtocommendtheorganizersofthisworkshop.ThefocusoftheworkshopisrelevanttotheagendaoftheFederalMinistryofPowerandSteelandaspirationsoftheFederalGovernmentofNigeriatoprovideregularandsteadyelectricitytomajorityofNigeriansbeforetheendofyear2001.

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