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简介：AbstractBackground:According to the Independent High-level Commission on Non-communicable Diseases (NCD) of the World Health Organization (WHO), global reduction in lung cancer mortality has been achieved since the year 2000, although this effect is not sufficient to reach the 30% reduction of mortality from NCDs by the year 2030, as stipulated by the United Nations Sustainable Development Goal 3.4. The objective of this study was to analyze whether the lifestyle changes implemented by the WHO at country level could have an impact on mortality from this form of cancer.Methods:WHO statistics, based on the unified mortality and causes-of-death reports of Member-State countries, were used to evaluate global lung cancer mortality trends and make comparisons and assessments of different types of community-based, country-wide interventions.Results:The lung cancer mortality decline was associated with the anti-tobacco campaign initiated by the WHO in the last 15 to 20 years. Comprehensive tobacco control remained the major and most successful lifestyle modification measure. In countries with declining lung cancer mortality, 91% of countries had decreasing tobacco prevalence in males and 82% in females. Country-wide measures to increase physical activity had a strong tendency to be better implemented in countries with declining lung cancer mortality (t = 1.79, P > 0.05). Other WHO "best-buy" lifestyle modification campaigns (diet and alcohol) had been carried out for shorter periods, and their associations with lung cancer were less strong than tobacco. There was no significant difference between countries with declining and increasing lung cancer mortality in the measures for reduction of harmful alcohol use (t= 0.92, P > 0.05) and unhealthy diet reduction measures (t= 0.84, P > 0.05).Conclusion:Following WHO "best-buys" should facilitate to move countries towards the NCD including lung cancer mortality reduction targets. Governments and communities must embrace these targets with coordinated effective action for better health.

简介：观察aerosolized组A的吸入的功效的目的链状球菌(气体)在在老鼠治疗orthotopic肺癌症的准备当模特儿并且为肺癌症估计这个管理模式的可行性，安全，和有效性。方法路易斯肺癌(LLC)房间紧张经由intrathoracic注射被管理建立orthotopic肺癌症老鼠模型。在忍受肿瘤的模型成功地被建立，由计算断层摄影术证实了以后，老鼠被吸入与aerosolized气体准备(煤气的组)或aerosolized正常管理盐(控制组)。aerosolized气体准备的反肿瘤效果组织学地被评估；同时，生活的幸存和质量在这二个组之间被比较。aerosolized气体准备显著地显示出的结果反肿瘤效果，在忍受肿瘤的老鼠引起orthotopic肺癌症房间的坏死。而且，在煤气的组的鼠标在控制组比那些有生活和更长的幸存的显著地更好的质量。aerosolized气体准备的吸入可以是肺癌症的一个可行、安全、有效的解决方案的结论。

简介：AbstractLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in vitro and in vivo. We summarized the recent 5 years of different research progress on clinical applications and antitumor mechanisms of TCM in the treatment of lung cancer. As a potent adjuvant therapy, TCM could enhance conventional treatments (chemotherapy, radiation therapy, and epidermal growth factor receptors [EGFRs] tyrosine kinase inhibitors [TKIs]) effects as well as provide synergistic effects, enhance chemotherapy drugs chemosensitivity, reverse drug resistance, reduce adverse reactions and toxicity, relieve patients’ pain and improve quality of life (QOL). After treating with TCM, lung cancer cells will induce apoptosis and/or autophagy, suppress metastasis, impact immune reaction, and therapeutic effect of EGFR-TKIs. Therefore, TCM is a promisingly potent adjuvant therapy in the treatment of lung cancer and its multiple mechanisms are worthy of an in-depth study.

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简介：Cancercelldormancyisthemaincauseofcancerrecurrenceandfailureoftherapyasdormantcellsevadenotonlytheanticancerdrugsbutalsothehostimmunesystem.Thesedormantcellsveilthemselvesfromdetectionbyimagingand/orusingbiomarkers,whichimposesanadditionalproblemintargetingsuchcells.Asimilarformofhibernationprocessknownasencystationisstudiedindetailforpathogenicunicellulareukaryoticmicroorganisms.Byexaminationusingmicroarraygeneexpressionprofiles,immunocytochemistrytools,andsiRNAsduringtheprocessofencystation,understandingthecovertfeaturesofcancercelldormancyasproposedcouldbepossible.Thisknowledgecanbeextendedtodormantcancercellstouncoverthemechanismsthatunderliethisghost,yetdangerousstateofhumancancers.Weproposeastrategytoinducedormancyandexitthisstatebyapplicationofknowledgegainedfromtheencystationinductionandretrievalprocessesinpathogeniceukaryoticmicroorganisms.Giventhatearlydetectionandcharacterizationofdormantmalignanttumorcellsisimportantasageneralstrategytomonitorandpreventthedevelopmentofovertmetastaticdisease,thishomologymayenablethedesignoftherapiesthatcouldeitherawakethedormantcellfromdormancytomakeitavailablefortherapiesorprolongsuchaphasetomakecancerappearasachronicdisease

简介：Hepatoma房间(Hepg2s)在氢氧根上有教养的同样典型的癌症房间(哦)并且甲基(CH3)组表面被显示展出不同增长和词法变化。Hepg2s房间在上哦表面在CH3表面上比那些更快成长了。Hepg2s房间在上哦表面有更大的接触区域和更多的弄平的形态学，当那些在CH3表面上展出了更小的接触时，区域和更多绕行形态学。在7天文化以后，进CH3表面上的簇的Hepg2s房间的迁居在OH表面上比那慢显著地表现了。这些化学上修改的表面在增长，粘附，和移植上展出了Hepg2s房间的规定，提供肝癌症的潜在的治疗。

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简介：AbstractLung cancer is the leading cause of cancer-related deaths worldwide. Approximately 10%-50% of patients experience relapse after radical surgery, which may be attributed to the persistence of minimal/molecular residual disease (MRD). Circulating tumor DNA (ctDNA), a common liquid biopsy approach, has been demonstrated to have significant clinical merit. In this study, we review the evidence supporting the use of ctDNA for MRD detection and discuss the potential clinical applications of postoperative MRD detection, including monitoring recurrence, guiding adjuvant treatment, and driving clinical trials in lung cancer. We will also discuss the problems that prevent the routine application of ctDNA MRD detection. Multi-analyte methods and identification of specific genetic and molecular alterations, especially methylation, are effective detection strategies and show considerable prospects for future development. Interventional prospective studies based on ctDNA detection are needed to determine whether the application of postoperative MRD detection can improve the clinical outcomes of lung cancer patients, and the accuracy, sensitivity, specificity, and robustness of different detection methods still require optimization and refinement.

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简介：Breastmetastasisfromextra-mammarymalignancyisrare.Anincidenceof0.4%to1.3%hasbeenreportedinliterature.Theprimarymalignanciesthatmostcommonlymetastasizetothebreastareleukemia,lymphoma,andmalignantmelanoma.Inthisreport,twocasesofpulmonarymetastasistothebreastwerepresented.A40-year-oldfemalemanifestedarightbreastmassof2-monthduration.Afterphysicalexaminationwasperformed,apoorlydefinedmasswasnotedintheupperouterquadrantoftherightbreast.Another49-year-oldfemalemanifestedrightbreastmassof5-dayduration.Apoorlydefinedmasswasnotedinthelowerinnerquadrantoftherightbreast.Mammographyresultsalsorevealedbreastcancer.Thepatientsunderwentlocalexcision.Afterhistologicalandimmunohistochemicalanalyseswereconducted,aprimarylungcarcinomathatmetastasizedtothebreastwasdiagnosed.Anaccuratedifferentiationofmetastasistothebreastfromprimarybreastcancerisveryimportantbecausethetreatmentandprognosisofthetwodiffersignificantly.

简介：Survivalratesformetastaticlungcancer,includingnon-smallcelllungcancer(NSCLC)andsmallcelllungcancer(SCLC),arepoorwith5-yearsurvivalsoflessthan5%.Theimmunesystemhasanintricateandcomplexrelationshipwithtumorigenesis;agroundswellofresearchontheimmunesystemisleadingtogreaterunderstandingofhowcancerprogressesandpresentingnewwaystohaltdiseaseprogress.Duetotheextraordinarypoweroftheimmunesystem—withitscapacityformemory,exquisitespecificityandcentralanduniversalroleinhumanbiology—immunotherapyhasthepotentialtoachievecomplete,long-lastingremissionsandcures,withfewsideeffectsforanycancerpatient,regardlessofcancertype.Asaresult,arangeofcancertherapiesareunderdevelopmentthatworkbyturningourownimmunecellsagainsttumors.Howeverdeeperunderstandingofthecomplexityofimmunomodulationbytumorsiskeytothedevelopmentofeffectiveimmunotherapies,especiallyinlungcancer.

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简介：Decane在人的呼吸是不稳定的有机化合物(VOC)之一。在人的呼吸的decane的成功的察觉为早肺癌症诊断有广阔前景。在这份报纸，基于过滤器表面检测设备的一篇小说声学的波浪(锯)气体传感器被介绍。与一部薄氧化graphene电影涂的锯传感器被用来每百万部分地检测decane(ppm)集中。控制和信号察觉电路与插入损失的察觉分辨率用一个向量网络分析器被设计在下面到0.0001dB。当暴露了到0.2ppmdecane时，结果证明SAW传感器能与大敏感快速反应。这台设备在医药诊断和环境评价显示出巨大的潜力。

简介：在病原体识别的像使用费的受体(TLR)的角色在最近的年里是快速地先进的。然而，进在非传染的织物损害的TLR的功能的调查刚开始了。以前，我们和其它表明了那碎裂的hyaluronan(哈)在织物损害期间积累。CD44被要求在织物损害期间清除HA，并且损害了清理哈在不停的发炎的结果。另外，碎裂哈在损害地点由煽动性的房间刺激煽动性的基因的表示。最近，我们识别了那哈碎片要求TLR2和TLR4刺激老鼠巨噬细胞生产煽动性的chemokines和cytokines。在一个非传染的肺损害模型，在TLR2和TLR4缺乏的老鼠显示出煽动性的房间的损害transepithelial迁居，增加的织物损害，提高的肺上皮的房间apoptosis，和减少的幸存。在高分子的质量的表示上的肺上皮的房间哈对尖锐的肺损害和apoptosis的保护的老鼠，部分地通过NF-kappaB的TLR依赖的基础激活。在TLR2和TLR4的夸大的损害缺乏的老鼠看起来由于上皮的房间上的损害HA-TLR相互作用。这些研究识别那个主机矩阵部件哈并且TLR相互作用提供开始煽动性的回答的信号，维持上皮的房间完整，并且支持从尖锐的肺损害的恢复。房间研究(2006)16：693-701。做i：10.1038/sj.cr.7310085；出版联机2006年8月8日。

简介：AbstractBackground:Previous studies have shown that bufalin exerts antitumor effects through various mechanisms. This study aimed to determine the antineoplastic mechanism of bufalin, an extract of traditional Chinese medicine toad venom, in ovarian cancer.Methods:The 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT), 5-ethynyl-2′-deoxyuridine (EdU), and colony formation assays were used to investigate the antiproliferative effect of bufalin on the ovarian cancer cell line SK-OV-3. Molecular docking was used to investigate the combination of bufalin and epidermal growth factor receptor (EGFR) protein. Western blotting was performed to detect the expression of EGFR protein and its downstream targets.Results:Bufalin inhibited the proliferation of SK-OV-3 cells in a dose- and time-dependent manner. Bufalin was confirmed to combine with EGFR protein using molecular docking and downregulate expression of EGFR. Bufalin inhibited phosphorylation of EGFR, protein kinase B (AKT), and extracellular signal-regulated kinase (ERK).Conclusion:Bufalin suppresses the proliferation of ovarian cancer cells through the EGFR/AKT/ERK signaling pathway.

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简介：MicroRNAs(miRNAs)内长的、小、非编码的RNA，它能够在post-transcriptional的silencing基因表示铺平。在这研究，我们报导miR-205是显著地在与匹配的正常的胸织物相比的胸肿瘤的underexpressed。同样，包括MCF-7和MDA-MB-231，乳癌房间行比非恶意的MCF-10A房间表示低级miR-205。兴趣，miR-205的宫外的表示显著地禁止房间增长和抛锚独立人士生长，以及房间侵略。而且，miR-205被显示在一个动物模型压制肺转移。最后，西方的污点与试金表明的酶记者结合了那ErbB3和脉管的endothelial生长因素A(VEGF--一)是为miR-205的直接目标，并且这miR-205-mediated抑制通过和在ErbB3和VEGF的3鈥?untranslated区域(3鈥?UTR)的通常认为的miR-205绑定地点的直接相互作用是可能的--一。一起，这些结果建议miR-205是在乳癌的肿瘤suppressor。

简介：ＡＮＴＩＣＯＭＰＬＥＭＥＮＴＡＲＹＡＣＴＩＶＩＴＹＩＮＨＵＭＡＮＳＥＲＵＭＯＦＬＵＮＧＣＡＮＣＥＲＰＡＴＩＥＮＴＳＡＮＤＩＴＳＰＯＳＳＩＢＬＥＣＬＩＮＩＣＡＬＳＩＧＮＩＦＩＣＡＮＣＥＬｉｕＨｕｉｒｏｎｇ刘慧荣ＬｉａｎｇＦｅｎｇ梁峰ＺｈａｎｇＷｅｉｆ...